Evidence map›Paper›PMID 24966472›Full record

ArticleMediators of inflammation2014

Hydrogen sulfide ameliorates ischemia/reperfusion-induced hepatitis by inhibiting apoptosis and autophagy pathways.

Ping Cheng, Fan Wang, Kan Chen, Miao Shen, Weiqi Dai, Ling Xu, Yan Zhang, Chengfen Wang, Jingjing Li, Jing Yang and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mediators of inflammation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.

  1. Pooled it
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  7. Review
  8. The Role of Hydrogen Sulfide Regulation of Autophagy in Liver Disorders.International journal of molecular sciences · 2022
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  14. Article
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  18. Exogenous HCell death & disease · 2017
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Ping ChengDepartment of Gastroenterology, The Tenth People's Hospital of Tongji University, Shanghai 200072, China.
Fan WangDepartment of Gastroenterology, The Tenth People's Hospital of Tongji University, Shanghai 200072, China.
Kan ChenDepartment of Gastroenterology, The Tenth People's Hospital of Tongji University, Shanghai 200072, China.
Miao ShenDepartment of Gastroenterology, The Tenth People's Hospital of Tongji University, Shanghai 200072, China.
Weiqi DaiDepartment of Gastroenterology, The Tenth People's Hospital of Tongji University, Shanghai 200072, China.
Ling XuDepartment of Gastroenterology, The Tenth People's Hospital of Tongji University, Shanghai 200072, China ; Department of Gastroenterology, The Tongren Hospital of Shanghai Jiaotong University, Shanghai 200050, China.
Yan ZhangDepartment of Gastroenterology, The Tenth People's Hospital of Tongji University, Shanghai 200072, China.
Chengfen WangDepartment of Gastroenterology, The Tenth People's Hospital of Tongji University, Shanghai 200072, China.
Jingjing LiDepartment of Gastroenterology, The Tenth People's Hospital of Tongji University, Shanghai 200072, China.
Jing YangDepartment of Gastroenterology, The Tenth People's Hospital of Tongji University, Shanghai 200072, China.
Rong ZhuDepartment of Gastroenterology, The Tenth People's Hospital of Tongji University, Shanghai 200072, China ; Department of Gastroenterology, Clinical Medical College of the Tenth People's Hospital of Nangjing Medical University, Shanghai 200072, China.
Huawei ZhangDepartment of Gastroenterology, The Tenth People's Hospital of Tongji University, Shanghai 200072, China ; Department of Gastroenterology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Yuanyuan ZhengDepartment of Gastroenterology, The Tenth People's Hospital of Tongji University, Shanghai 200072, China.
Jie LuDepartment of Gastroenterology, The Tenth People's Hospital of Tongji University, Shanghai 200072, China.
Yingqun ZhouDepartment of Gastroenterology, The Tenth People's Hospital of Tongji University, Shanghai 200072, China.
Chuanyong GuoDepartment of Gastroenterology, The Tenth People's Hospital of Tongji University, Shanghai 200072, China.
Tongji University · CNShanghai Tenth People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHepatic ischemia/reperfusion (I/R) injury is an important clinical problem, and its consequences can seriously threaten human health. Apoptosis and autophagy have been shown to contribute to cell death in hepatic I/R injury. Hydrogen sulfide (H2S) is the third most common endogenously produced gaseous signaling molecule and is known to exert a protective effect against hepatic I/R injury. In this study, the purpose is to explore both the effect and mechanism of H2S on hepatic I/R injury.

methodsBalb/c mice were randomized into Sham, I/R, or two doses (14 μmol/kg and 28 μmol/kg) of sodium hydrosulfide (NaHS, an H2S donor) preconditioning groups.

resultsNaHS significantly reduced the levels of TNF- α and IL-6 at 12 h and 24 h after injection compared with ischemia/reperfusion challenge alone. The expression of Bcl-2, Bax, Beclin-1, and LC3, which play important roles in the regulation of the apoptosis and autophagy pathways, was also clearly affected by NaHS. Furthermore, NaHS affected the p-JNK1, p-ERK1, and p-p38.

conclusionOur results indicate that H2S attenuates hepatic I/R injury, at least in part, by regulating apoptosis through inhibiting JNK1 signaling. The autophagy agonist rapamycin potentiated this hepatoprotective effect by reversing the inhibition of autophagy by H2S.

Indexed as

ApoptosisAutophagyAnimalsApoptosis Regulatory Proteinsbcl-2-Associated X ProteinBeclin-1HepatitisHumansHydrogen SulfideInterleukin-6LiverMaleMiceMice, Inbred BALB CMicrotubule-Associated ProteinsProto-Oncogene Proteins c-bcl-2Apoptosis Regulatory ProteinsBax protein, mousebcl-2-Associated X ProteinBeclin-1Becn1 protein, mouseHydrogen SulfideInterleukin-6Map1lc3b protein, mouseMicrotubule-Associated ProteinsProto-Oncogene Proteins c-bcl-2sodium bisulfideSulfidesTumor Necrosis Factor-alpha

Identifiers

PMID24966472
PMCPMC4055384
OpenAlexW2018691447

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.