ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Global intracellular slow-wave dynamics of the thalamocortical system.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.
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Who cites it
84 citing papers in PubMed, 155 citations in OpenAlex.
- Closed-loop modulation of sleep in children undergoing intracranial recordings.Cell reports. Medicine · 2026Trial
- Lag threads organize the brain's intrinsic activity.Proceedings of the National Academy of Sciences of the United States of America · 2015Trial
- Thalamic involvement defines distinct slow-wave subtypes in NREM sleep.Communications biology · 2026Article
- Implication of the thalamus in sleep alterations observed in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Local infrared stimulation modulates spontaneous cortical slow wave dynamics in anesthetized rats.Scientific reports · 2026Article
- Pathway-Specific Ultrastructure of Thalamocortical Synapses in Mouse Somatosensory Area S2.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Thalamic involvement defines distinct slow-wave subtypes in NREM sleep.Research square · 2025Article
- Global and local nature of cortical slow waves.iScience · 2025Article
- Time-resolved large-scale neural coactivations in macaque monkey.NeuroImage · 2025Article
- Thalamic involvement defines distinct slow-wave subtypes in NREM sleep.bioRxiv : the preprint server for biology · 2025Article
- A Distinct Down-to-Up Transition Assembly in the Retrosplenial Cortex during Slow-Wave Sleep.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- The reuniens nucleus of the thalamus facilitates hippocampo-cortical dialogue during sleep.eLife · 2025Article
- Multi-scale spiking network model of human cerebral cortex.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Intracortical mechanisms of single pulse electrical stimulation (SPES) evoked excitations and inhibitions in humans.Scientific reports · 2024Article
- Sleep and wake in a model of the thalamocortical system with Martinotti cells.The European journal of neuroscience · 2024Article
- A modular and adaptable analysis pipeline to compare slow cerebral rhythms across heterogeneous datasets.Cell reports methods · 2024Article
- Audiovisualization of real-time neuroimaging data.PloS one · 2024Article
- From macro to micro: slow-wave sleep and its pivotal health implications.Frontiers in sleep · 2024Review
- Diversity of cortical activity changes beyond depression during Spreading Depolarizations.Nature communications · 2023Article
- Entorhinal cortical delta oscillations drive memory consolidation.Cell reports · 2023Article
24 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
It is widely accepted that corticothalamic neurons recruit the thalamus in slow oscillation, but global slow-wave thalamocortical dynamics have never been experimentally shown. We analyzed intracellular activities of neurons either from different cortical areas or from a variety of specific and nonspecific thalamic nuclei in relation to the phase of global EEG signal in ketamine-xylazine anesthetized mice. We found that, on average, slow-wave active states started off within frontal cortical areas as well as higher-order and intralaminar thalamus (posterior and parafascicular nuclei) simultaneously. Then, the leading edge of active states propagated in the anteroposterior/lateral direction over the cortex at ∼40 mm/s. The latest structure we recorded within the slow-wave cycle was the anterior thalamus, which followed active states of the retrosplenial cortex. Active states from different cortical areas tended to terminate simultaneously. Sensory thalamic ventral posterior medial and lateral geniculate nuclei followed cortical active states with major inhibitory and weak tonic-like "modulator" EPSPs. In these nuclei, sharp-rising, large-amplitude EPSPs ("drivers") were not modulated by cortical slow waves, suggesting their origin in ascending pathways. The thalamic active states in other investigated nuclei were composed of depolarization: some revealing "driver"- and "modulator"-like EPSPs, others showing "modulator"-like EPSPs only. We conclude that sensory thalamic nuclei follow the propagating cortical waves, whereas neurons from higher-order thalamic nuclei display "hub dynamics" and thus may contribute to the generation of cortical slow waves.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.