Evidence map›Paper›PMID 24966358›Full record

ArticleJournal of clinical microbiology2014

Identification of occult Fusobacterium nucleatum central nervous system infection by use of PCR-electrospray ionization mass spectrometry.

Sudha Nagalingam, Michelle Lisgaris, Benigno Rodriguez, Michael R Jacobs, Michael Lederman, Robert A Salata, Andrea M Hujer, Atis Muehlenbachs, Marlene DeLeon-Carnes, John J Farrell and 2 more

Open access · bronzeAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Brain Abscess: A Rare Clinical Case with Oral Etiology.Case reports in infectious diseases · 2022
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Sudha NagalingamDepartment of Medicine, Division of Infectious Disease and HIV Medicine, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio, USA.
Michelle LisgarisDepartment of Medicine, Division of Infectious Disease and HIV Medicine, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio, USA.
Benigno RodriguezDepartment of Medicine, Division of Infectious Disease and HIV Medicine, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio, USA.
Michael R JacobsDepartment of Pathology, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio, USA.
Michael LedermanDepartment of Medicine, Division of Infectious Disease and HIV Medicine, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio, USA.
Robert A SalataDepartment of Medicine, Division of Infectious Disease and HIV Medicine, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio, USA.
Andrea M HujerDepartment of Medicine, Division of Infectious Disease and HIV Medicine, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio, USA Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA.
Atis MuehlenbachsInfectious Diseases Pathology Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Marlene DeLeon-CarnesInfectious Diseases Pathology Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
John J FarrellDepartment of Medicine, University of Illinois School of Medicine, Peoria, Illinois, USA.
Rangarajan SampathIbis Biosciences, an Abbott Company, Carlsbad, California, USA.ORCID http://orcid.org/0000-0002-2951-6372
Robert A BonomoResearch Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA Departments of Pharmacology, Microbiology and Molecular Biology, Case Western Reserve University, Cleveland, Ohio, USA Robert.bonomo@va.gov.
Case Western Reserve University · USUniversity Hospitals Case Medical Center · USCenters for Disease Control and Prevention · USAbbott (United States) · USUniversity of Illinois Urbana-Champaign · US

Funding

Antibacterial Resistance Leadership Group (ARLG)UM1AI104681 · NIAID · DUKE UNIVERSITY · PI Vance G. Fowler, Henry F HENRY CHAMBERS · 2013 to 2026
$180.8M
Understanding ceftazidime resistance in SHV B-LactamasesR01AI063517 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI BONOMO, ROBERT A. · 2005 to 2023
$4.9M
A Mechanism-Based Approach to Metallo-beta-Lactamase InhibitionR01AI100560 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI BONOMO, ROBERT A., SPENCER, JAMES · 2012 to 2022
$4.4M
The Continuing Challenge of Carbapenemases in K. pneumoniae: KPC-2 & NDM-1I01BX001974 · VA · LOUIS STOKES CLEVELAND VA MEDICAL CENTER · PI BONOMO, ROBERT A. · 2013 to 2024
–
BLRD VA I01 BX001974NIAID NIH HHS R01 AI063517NIAID NIH HHS R01AI063517NIAID NIH HHS R01 AI100560NIAID NIH HHS R01AI100560NIAID NIH HHS UM1 AI104681NIAID NIH HHS UM1AI104681
6 · The paper itself

Abstract

Anaerobic bacteria are often difficult to detect, especially after the initiation of antibiotics. We describe the application of PCR-electrospray ionization mass spectrometry (PCR/ESI-MS) using a sample of cerebrospinal fluid to identify an anaerobic Gram-negative bacillus, Fusobacterium nucleatum, in a patient with "culture-negative" meningitis and cerebral abscesses.

Indexed as

Polymerase Chain ReactionSpectrometry, Mass, Electrospray IonizationAdultAnti-Bacterial AgentsBiopsyBrain AbscessCerebrospinal FluidFusobacterium InfectionsFusobacterium nucleatumHeadHistocytochemistryHumansMagnetic Resonance ImagingMaleMeningitis, BacterialMicroscopyAnti-Bacterial Agents

Identifiers

PMID24966358
PMCPMC4313185
OpenAlexW2117808080

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.