Evidence map›Paper›PMID 24966357›Full record

ArticleJournal of clinical microbiology2014

Microevolution of Burkholderia pseudomallei during an acute infection.

Direk Limmathurotsakul, Matthew T G Holden, Paul Coupland, Erin P Price, Narisara Chantratita, Vanaporn Wuthiekanun, Premjit Amornchai, Julian Parkhill, Sharon J Peacock

Abstract readCase Reports
In one paragraph

Article in Journal of clinical microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Phenotypic and genetic alterations ofFrontiers in microbiology · 2023
    Article
  5. Article
  6. Human Melioidosis.Clinical microbiology reviews · 2020
    Review
  7. Article
  8. An Evolutionary Arms Race BetweenFrontiers in microbiology · 2020
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Direk LimmathurotsakulDepartment of Tropical Medicine and Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand direk@tropmedres.ac.
Matthew T G HoldenThe Wellcome Trust Sanger Institute, Cambridge, United Kingdom.
Paul CouplandThe Wellcome Trust Sanger Institute, Cambridge, United Kingdom.
Erin P PriceGlobal and Tropical Health Division, Menzies School of Health Research, Darwin, Australia.
Narisara ChantratitaMahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Vanaporn WuthiekanunMahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Premjit AmornchaiMahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Julian ParkhillThe Wellcome Trust Sanger Institute, Cambridge, United Kingdom.ORCID http://orcid.org/0000-0002-7069-5958
Sharon J PeacockDepartment of Medicine, Cambridge University, Addenbrooke's Hospital, Cambridge, United Kingdom.

Funding

Wellcome TrustWellcome Trust 090219/Z/09/ZWellcome Trust 098051Wellcome Trust 101103/Z/13/Z
6 · The paper itself

Abstract

We used whole-genome sequencing to evaluate 69 independent colonies of Burkholderia pseudomallei isolated from seven body sites of a patient with acute disseminated melioidosis. Fourteen closely related genotypes were found, providing evidence for the rapid in vivo diversification of B. pseudomallei after inoculation and systemic spread.

Indexed as

Evolution, MolecularGenetic VariationBurkholderia pseudomalleiDNA, BacterialGenome, BacterialGenotypeHumansMaleMelioidosisMolecular Sequence DataSequence Analysis, DNAYoung AdultDNA, Bacterial

Identifiers

PMID24966357
PMCPMC4313173

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.