ArticleProceedings. Biological sciences2014
Morphological and histological adaptation of muscle and bone to loading induced by repetitive activation of muscle.
Article in Proceedings. Biological sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 35 citations in OpenAlex.
- Exploring osteosarcopenia from the gut microbiota perspective: mechanistic insights and therapeutic potentials based on the gut-muscle-bone Axis.Frontiers in microbiology · 2026Review
- Are we giving too much weight to lean mass loss?Molecular metabolism · 2025Review
- Contrast-enhanced Micro-CT imaging of a foetal female pelvic floor reveals anatomical details.PloS one · 2025Article
- Bone Tissue Responsiveness To Mechanical Loading-Possible Long-Term Implications of Swimming on Bone Health and Bone Development.Current osteoporosis reports · 2022Review
- MiniVStimA: A miniaturized easy to use implantable electrical stimulator for small laboratory animals.PloS one · 2020Article
- Patient-Specific Bone Multiscale Modelling, Fracture Simulation and Risk Analysis-A Survey.Materials (Basel, Switzerland) · 2019Review
- Experimental evidence that physical activity affects the multivariate associations among muscle attachments (entheses).The Journal of experimental biology · 2019Article
- Experimental proof that multivariate patterns among muscle attachments (entheses) can reflect repetitive muscle use.Scientific reports · 2019Article
- In-situ measurements of tensile forces in the tibialis anterior tendon of the rat in concentric, isometric, and resisted co-contractions.Physiological reports · 2017Article
- A novel miniature in-line load-cell to measure in-situ tensile forces in the tibialis anterior tendon of rats.PloS one · 2017Article
- Does subchondral bone of the equine proximal phalanx adapt to race training?Journal of anatomy · 2016Article
- Diffusible iodine-based contrast-enhanced computed tomography (diceCT): an emerging tool for rapid, high-resolution, 3-D imaging of metazoan soft tissues.Journal of anatomy · 2016Review
- Quantification of Alterations in Cortical Bone Geometry Using Site Specificity Software in Mouse models of Aging and the Responses to Ovariectomy and Altered Loading.Frontiers in endocrinology · 2015Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Muscular contraction plays a pivotal role in the mechanical environment of bone, but controlled muscular contractions are rarely used to study the response of bone to mechanical stimuli. Here, we use implantable stimulators to elicit programmed contractions of the rat tibialis anterior (TA) muscle. Miniature stimulators were implanted in Wistar rats (n = 9) to induce contraction of the left TA every 30 s for 28 days. The right limb was used as a contralateral control. Hindlimbs were imaged using microCT. Image data were used for bone measurements, and to construct a finite-element (FE) model simulation of TA forces propagating through the bone. This simulation was used to target subsequent bone histology and measurement of micromechanical properties to areas of high strain. FE mapping of simulated strains revealed peak values in the anterodistal region of the tibia (640 µε ± 30.4 µε). This region showed significant increases in cross-sectional area (28.61%, p < 0.05) and bone volume (30.29%, p < 0.05) in the stimulated limb. Histology revealed a large region of new bone, containing clusters of chondrocytes, indicative of endochondral ossification. The new bone region had a lower elastic modulus (8.8 ± 2.2 GPa) when compared with established bone (20 ± 1.4 GPa). Our study provides compelling new evidence of the interplay between muscle and bone.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.