Evidence map›Paper›PMID 24966245›Full record

ArticleJournal of feline medicine and surgery2015

Utility of feline coronavirus antibody tests.

Diane D Addie, Sophie le Poder, Paul Burr, Nicola Decaro, Elizabeth Graham, Regina Hofmann-Lehmann, Oswald Jarrett, Michael McDonald, Marina L Meli

Open access · bronzeAbstract readComparative Study
In one paragraph

Article in Journal of feline medicine and surgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 49 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 4 countries.

Diane D AddieUniversity of Glasgow Veterinary School, Glasgow, UK draddie@btinternet.com.
Sophie le PoderUMR 1161-Virologie-INRA-ENVA-ANSES, Maisons-Alfort, France.
Paul BurrBiobest Laboratories Ltd, The Edinburgh Technopole, Penicuik, UK.
Nicola DecaroDepartment of Veterinary Medicine, University of Bari, Bari, Italy.
Elizabeth GrahamUniversity of Glasgow Veterinary School, Glasgow, UK.
Regina Hofmann-LehmannClinical Laboratory, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.
Oswald JarrettUniversity of Glasgow Veterinary School, Glasgow, UK.
Michael McDonaldUniversity of Glasgow Veterinary School, Glasgow, UK.
Marina L MeliClinical Laboratory, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.
University of Glasgow · GBUniversity of Zurich · CHNeuroDiderot · FRUniversity of Bari Aldo Moro · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Eight different tests for antibodies to feline coronavirus (FCoV) were evaluated for attributes that are important in situations in veterinary practice. We compared four indirect immunofluorescent antibody tests (IFAT), one enzyme-linked immunosorbent assay (ELISA) (FCoV Immunocomb; Biogal) and three rapid immunochromatographic (RIM) tests against a panel of samples designated by consensus as positive or negative. Specificity was 100% for all but the two IFATs based on transmissible gastroenteritis virus (TGEV), at 83.3% and 97.5%. The IFAT and ELISA tests were best for obtaining an antibody titre and for working in the presence of virus. The RIM tests were the best for obtaining a result quickly (10-15 mins); of these, the Speed F-Corona was the most sensitive, at 92.4%, followed by FASTest feline infectious peritonitis (FIP; 84.6%) and Anigen Rapid FCoV antibody test (64.1%). Sensitivity was 100% for the ELISA, one FCoV IFAT and one TGEV IFAT; and 98.2% for a second TGEV IFA and 96.1% for a second FCoV IFAT. All tests worked with effusions, even when only blood products were stipulated in the instruction manual. The ELISA and Anigen RIM tests were best for small quantities of sample. The most appropriate FCoV antibody test to use depends on the reason for testing: in excluding a diagnosis of FIP, sensitivity, specificity, small sample quantity, rapidity and ability to work in the presence of virus all matter. For FCoV screening, speed and sensitivity are important, and for FCoV elimination antibody titre is essential.

Indexed as

AnimalsAntibodies, ViralCatsCoronavirus, FelineCoronavirus InfectionsEnzyme-Linked Immunosorbent AssayFeline Infectious PeritonitisFluorescent Antibody Technique, DirectFluorescent Antibody Technique, IndirectSensitivity and SpecificityAntibodies, Viral

Identifiers

PMID24966245
PMCPMC10816424
OpenAlexW2170121561

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.