Evidence map›Paper›PMID 24966231›Full record

SynthesisJournal of dental research2014

Effect of alveolar ridge preservation after tooth extraction: a systematic review and meta-analysis.

G Avila-Ortiz, S Elangovan, K W O Kramer, D Blanchette, D V Dawson

11 registry-linked trialsOpen access · greenAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of dental research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 11 registered trials, which are not on this map. Cited by 201 papers, 16 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
201citing papers in PubMed, 16 pooled it
29.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02952209 naunknown statusnot on this mapstarted 2016, after this paper: background citation

The Effect of Alveolar Ridge Preservation After Tooth Extraction in the Posterior Maxilla: A Randomized, Split-Mouth, Controlled Trial.

TypeinterventionalSponsorNYU College of DentistryRan2016 to 2021Enrolled15ConditionsTooth ExtractionArmsXenograft
NCT03659617 nacompletednot on this mapstarted 2018, after this paper: background citation

Clinical, Radiographic and Histomorphotmetric Analysis of Healing Dynamics in Human Extraction Sockets Grafted With Bio-Oss Collagen®: A Prospective 3-year Post-loading Study

TypeinterventionalSponsorUniversity of IowaRan2018 to 2025Enrolled39ConditionsTooth LossArmsxenograft (BioOss Collagen)
NCT03851289 nacompletednot on this mapstarted 2016, after this paper: background citation

Combination of Platelet-Rich Fibrin and Calcium Sulfate in Socket Augmentation

TypeinterventionalSponsorUniversity of MalayaRan2016 to 2018Enrolled10ConditionsTooth ExtractionArmsplatelet-rich fibrin and calcium sulfate, platelet-rich fibrin and xenograft
NCT03985033 nacompletednot on this mapstarted 2019, after this paper: background citation

The Clinical and Biological Effects of Leucocyte and Platelet-rich Fibrin (L-PRF) on Post-extraction Sockets Healing: a Randomized Controlled Trial

TypeinterventionalSponsorThe European Research Group on Periodontology (ERGOPerio)Ran2019 to 2021Enrolled18ConditionsTooth ExtractionArmsleucocyte and platelet-rich fibrin (L-PRF)
NCT04255342 naterminatednot on this mapstarted 2020, after this paper: background citation

Clinical, Radiographic, and Histomorphometric Analysis of AstraTech Implant EV Placed and Immediately Provisionalized Into Preserved Alveolar Ridges: A Prospective 3-Year Outcomes Study

TypeinterventionalSponsorChristopher BarwaczRan2020 to 2024Enrolled25ConditionsTooth LossArmsImplant Placement and Temporary Crown using AstraTech Implant System EV, Final Crown Delivery
NCT04741607 narecruitingnot on this mapstarted 2021, after this paper: background citation

Alveolar Ridge Preservation With Immediate or Late Implant Placement: a Multicenter Randomized Controlled Trial

TypeinterventionalSponsorUniversity GhentRan2021 to 2028Enrolled60ConditionsEstheticsArmsImplant placement (BLX implant system, Straumann, Basel, Switzerland), Ridge preservation (Bio-Oss Collagen 250 mg, Geistlich Pharma AG, Wolhusen, Switserland), Socket seal (Mucograft Seal, Geistlich Pharma AG, Wolhusen, Switserland)
NCT05505084 completednot on this mapstarted 2022, after this paper: background citation

Comparison of Five Distinct Membranes for Preservation of the Alveolar Ridge Following Tooth Extraction: A Prospective, Randomized, Controlled Clinical Study

Typeobservational_patient_registrySponsorUniversity of PennsylvaniaRan2022 to 2025Enrolled47ConditionsTooth Fractures, Tooth Extraction Status Nos, CariesArmsTooth extraction and ridge preservation using different barrier mermbranes
NCT06150456 phase1completednot on this mapstarted 2022, after this paper: background citation

Evaluation of Alveolar Bone Preservation After Molar Extraction Using Photobiomodulation Combined With Grafting With Scaffold Biomaterial: Clinical, Randomized, Triple-blind Study.

TypeinterventionalSponsorUniversity of Nove de JulhoRan2022 to 2022Enrolled60ConditionsExtracting Own Teeth, Bone SubstitutesArmsextraction, low level laser therapy, Plenum® OSShp and Plenum® Guide
NCT06164626 phase1unknown statusnot on this mapstarted 2023, after this paper: background citation

Evaluation of Alveolar Bone Preservation After Early Molar Extraction Using Photobiomodulation Combined With Grafting With Scaffold Biomaterial: Clinical, Randomized, Triple-blind Study.

TypeinterventionalSponsorUniversity of Nove de JulhoRan2023 to 2024Enrolled60ConditionsExtracting Own Teeth, Bone SubstitutesArmsExtraction, low level laser therapy, Plenum® OSShp and Plenum® Guide
NCT06275789 narecruitingnot on this mapstarted 2024, after this paper: background citation

Mix of Demineralized Freeze-Dried Bone Allograft and Deproteinized Bovine Bone Mineral: a Possible Solution for Alveolar Ridge Preservation?

TypeinterventionalSponsorNova Southeastern UniversityRan2024 to 2026Enrolled30ConditionsAlveolar Ridge Preservation, Dental Extraction, Bone GraftArmsAlveolar ridge preservation
NCT06654141 narecruitingnot on this mapstarted 2025, after this paper: background citation

Influence of Healing Time on the Outcomes of Alveolar Ridge Preservation in Periodontally Compromised Extraction Sockets: a Randomized Controlled Trial

TypeinterventionalSponsorShanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong UniversityRan2025 to 2029Enrolled42ConditionsTooth LossArmsAlveolar ridge preservation
3 · Its place in the literature

Who cites it

201 citing papers in PubMed, 16 syntheses or guidelines pooled it, 424 citations in OpenAlex.

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141 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

G Avila-OrtizDepartment of Periodontics, The University of Iowa, Iowa City, IA, USA gustavo-avila@uiowa.edu.
S ElangovanDepartment of Periodontics, The University of Iowa, Iowa City, IA, USA.
K W O KramerDivision of Biostatistics and Research Design, Dows Institute for Dental Research, The University of Iowa, Iowa City, IA, USA Health Integrity, LLC, Easton, MD, USA.
D BlanchetteDivision of Biostatistics and Research Design, Dows Institute for Dental Research, The University of Iowa, Iowa City, IA, USA.
D V DawsonDivision of Biostatistics and Research Design, Dows Institute for Dental Research, The University of Iowa, Iowa City, IA, USA.
University of Iowa · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alveolar ridge preservation strategies are indicated to minimize the loss of ridge volume that typically follows tooth extraction. The aim of this systematic review was to determine the effect that socket filling with a bone grafting material has on the prevention of postextraction alveolar ridge volume loss as compared with tooth extraction alone in nonmolar teeth. Five electronic databases were searched to identify randomized clinical trials that fulfilled the eligibility criteria. Literature screening and article selection were conducted by 3 independent reviewers, while data extraction was performed by 2 independent reviewers. Outcome measures were mean horizontal ridge changes (buccolingual) and vertical ridge changes (midbuccal, midlingual, mesial, and distal). The influence of several variables of interest (i.e., flap elevation, membrane usage, and type of bone substitute employed) on the outcomes of ridge preservation therapy was explored via subgroup analyses. We found that alveolar ridge preservation is effective in limiting physiologic ridge reduction as compared with tooth extraction alone. The clinical magnitude of the effect was 1.89 mm (95% confidence interval [CI]: 1.41, 2.36; p < .001) in terms of buccolingual width, 2.07 mm (95% CI: 1.03, 3.12; p < .001) for midbuccal height, 1.18 mm (95% CI: 0.17, 2.19; p = .022) for midlingual height, 0.48 mm (95% CI: 0.18, 0.79; p = .002) for mesial height, and 0.24 mm (95% CI: -0.05, 0.53; p = .102) for distal height changes. Subgroup analyses revealed that flap elevation, the usage of a membrane, and the application of a xenograft or an allograft are associated with superior outcomes, particularly on midbuccal and midlingual height preservation.

Indexed as

Tooth ExtractionAlveolar Bone LossAlveolar ProcessAlveolar Ridge AugmentationBone TransplantationHumansMembranes, ArtificialRandomized Controlled Trials as TopicSurgical FlapsTooth SocketMembranes, Artificialalveolar bone atrophyalveolar bone graftingalveolar bone lossbone remodelingevidence-based dentistrytooth loss

Identifiers

PMID24966231
PMCPMC4293706
OpenAlexW2162925058

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

and 5 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.