ArticleAmerican journal of epidemiology2014
Invited commentary: how exposure to air pollution may shape dementia risk, and what epidemiology can say about it.
Article in American journal of epidemiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Exposure to air pollution as a potential contributor to cognitive function, cognitive decline, brain imaging, and dementia: A systematic review of epidemiologic research.Neurotoxicology · 2016Pooled it
- Ambient air pollution and depressed mood in the National Longitudinal Study of Adolescent to Adult Health (Add Health) wave 4.American journal of epidemiology · 2025Article
- Effects of subchronic dietary exposure to the engineered nanomaterials SiOParticle and fibre toxicology · 2022Article
- Mental health mediators of subjective cognitive concerns among World Trade Center responders.Journal of psychiatric research · 2021Article
- Ambient fine particulate matter exposure and incident mild cognitive impairment and dementia.Journal of the American Geriatrics Society · 2021Article
- Neurodegenerative hospital admissions and long-term exposure to ambient fine particle air pollution.Annals of epidemiology · 2021Article
- The role of cardiovascular disease in the relationship between air pollution and incident dementia: a population-based cohort study.International journal of epidemiology · 2020Article
- Environmental Factors in Successful Aging: The Potential Impact of Air Pollution.Environmental health perspectives · 2019Article
- Are noise and air pollution related to the incidence of dementia? A cohort study in London, England.BMJ open · 2018Article
- A general neurologist's perspective on the urgent need to apply resilience thinking to the prevention and treatment of Alzheimer's disease.Alzheimer's & dementia (New York, N. Y.) · 2017Review
- Particulate Air Pollutants, Brain Structure, and Neurocognitive Disorders in Older Women.Research report (Health Effects Institute) · 2017Article
- Diesel engine exhaust accelerates plaque formation in a mouse model of Alzheimer's disease.Particle and fibre toxicology · 2017Article
- Traffic-Related Air Pollution and Dementia Incidence in Northern Sweden: A Longitudinal Study.Environmental health perspectives · 2016Article
- Cognitive decline and the neighborhood environment.Annals of epidemiology · 2015Article
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Abstract
The number of Americans with Alzheimer's disease (AD) dementia is expected to triple by 2050. No effective treatments exist, and prevention research has focused on behaviors and medical conditions, which have been difficult to modify at the population level. Cardiovascular disease epidemiology can inform the search for AD risk factors; exposure to fine particulate matter (PM) air pollution increases cardiovascular risk, pollutant regulations appear to reduce cardiovascular deaths, and vascular pathology influences dementia risk. In this issue of the Journal, Ailshire and Crimmins (Am J Epidemiol. 2014;180(4):359-366) report analyses of data from 14,000 older adults living across the United States, indicating an inverse association between exposure to PM and cognitive function, an outcome related to AD by virtue of the long period of cognitive decline that precedes clinical disease. Their work joins a growing body of data linking PM exposure to AD risk. If these data reflect causality, PM exposure would be 1 of few AD risk factors that are not only widespread, but that also can be modified at the population level using regulatory intervention. Active collaboration between air pollution and dementia epidemiologists will be critical for refining the available evidence and filling fundamental gaps, including the lack of studies on AD itself.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.