Evidence map›Paper›PMID 24966138›Full record

ArticleCurrent HIV/AIDS reports2014

Functional impairment, disability, and frailty in adults aging with HIV-infection.

Kristine M Erlandson, Jennifer A Schrack, Catherine M Jankowski, Todd T Brown, Thomas B Campbell

Abstract read
In one paragraph

Article in Current HIV/AIDS reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
100citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

100 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. A Fall Prevention Feasibility Trial for People With HIV and Alcohol Use.OTJR : occupation, participation and health · 2025
    Trial
  6. Trial
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Muscle Quality and Physical Function in Men With and Without HIV.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024
    Article
  20. Expert Consensus Statement on an Updated Definition of Unintended Weight Loss Among Persons With Human Immunodeficiency Virus in the Modern Treatment Era.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024
    Review

40 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kristine M ErlandsonDepartment of Medicine, Divisions of Infectious Diseases, University of Colorado, 12700 E. 19th Avenue, Mail Stop B168, Aurora, CO, 80045, USA, kristine.erlandson@ucdenver.edu.
Jennifer A Schrack
Catherine M Jankowski
Todd T Brown
Thomas B Campbell

Funding

UNIVERSITY OF COLORADO HIV RESEARCH TRAINING PROGRAMT32AI007447 · NIAID · UNIVERSITY OF COLORADO DENVER · PI CAMPBELL, THOMAS B. · 1992 to 2016
$2.8M
The Impact of HIV and Aging on Physical Function and the Somatopause.K23AG050260 · NIA · UNIVERSITY OF COLORADO DENVER · PI ERLANDSON, KRISTINE MACE · 2014 to 2018
$946k
Energy Expenditure, Activity, and Aging With HIV:Effects on Functional LongevityK01AG048765 · NIA · JOHNS HOPKINS UNIVERSITY · PI SCHRACK, JENNIFER ANN · 2014 to 2016
$388k
Mechanisms of Frailty in HIV-1 InfectionR03AG040594 · NIA · UNIVERSITY OF COLORADO DENVER · PI ERLANDSON, KRISTINE MACE · 2011 to 2012
$153k
NIAID NIH HHS T32 AI007447NIA NIH HHS K01 AG048765NIA NIH HHS K23 AG050260NIA NIH HHS R03 AG040594NIA NIH HHS R03AG040594-01
6 · The paper itself

Abstract

The integration of antiretroviral therapy (i.e., ART) into HIV care has dramatically extended the life expectancy of those living with HIV. However, in comparison to similar HIV-uninfected populations, HIV-infected persons experience an excess of morbidity and mortality with an early onset of aging complications including neurocognitive decline, osteoporosis, impaired physical function, frailty, and falls. Recent consensus guidelines encourage clinicians and researchers to consider functional impairment of HIV-infected adults as a measure to understand the impact of aging across a range of abilities. Despite the importance of assessing function in persons aging with HIV infection, a lack of consistent terminology and standardization of assessment tools has limited the application of functional assessments in clinical or research settings. Herein, we distinguish between different approaches used to assess function, describe what is known about function in the aging HIV population, and consider directions for future research.

Indexed as

AgingAdultAnti-HIV AgentsHIV InfectionsHumansQuality of LifeAnti-HIV Agents

Identifiers

PMID24966138
PMCPMC4125474

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.