ArticleThe Laryngoscope2014
Classification for animal vocal fold surgery: resection margins impact histological outcomes of vocal fold injury.
Article in The Laryngoscope, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 21 citations in OpenAlex.
- Exploring the Correlation Between Surgical Depth and Postoperative Voice Rest Duration in a Rabbit Phonomicrosurgery Model.World journal of otorhinolaryngology - head and neck surgery · 2026Article
- Transmuscular vocal fold injury reduces frequency complexity of rat ultrasonic vocalizations.Behavioural brain research · 2026Article
- Preclinical Vocal Fold and Airway Injury Models: A Scoping Review.Laryngoscope investigative otolaryngology · 2025Review
- Establishing a Mouse Model of Surgical Vocal Fold Injury.The Laryngoscope · 2025Article
- Reinke Edema: Factors that Interfere with Vocal Recovery after Surgery.International archives of otorhinolaryngology · 2023Article
- The role of systemic dehydration in vocal fold healing: Preliminary findings.Laryngoscope investigative otolaryngology · 2022Article
- Voice rest after vocal fold polyp surgery: A Swedish register study of 588 patients.Laryngoscope investigative otolaryngology · 2022Article
- Voice Handicap Index Changes After Microflap Surgery for Benign Vocal Fold Lesions Are Not Associated With Recommended Absolute Voice Rest Duration.American journal of speech-language pathology · 2022Article
- Vocal fold injury models in rats: a literature review on techniques and methodology.Journal of medicine and life · 2022Review
- Experimental model for controlled endoscopic subepithelial vocal fold injury in rats.Acta cirurgica brasileira · 2022Article
- Tissue-Engineered Vocal Fold Mucosa Implantation in Rabbits.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2016Article
- Epidermal growth factor mediated healing in stem cell-derived vocal fold mucosa.The Journal of surgical research · 2015Article
- Microarray-based characterization of differential gene expression during vocal fold wound healing in rats.Disease models & mechanisms · 2015Article
- Article
- Epithelial cells are active participants in vocal fold wound healing: an in vivo animal model of injury.PloS one · 2014Article
- Regenerative potential of basic fibroblast growth factor contained in biodegradable gelatin hydrogel microspheres applied following vocal fold injury: Early effect on tissue repair in a rabbit model.Brazilian journal of otorhinolaryngologyArticle
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
objectives/hypothesisExtent of vocal fold injury impacts the nature and timing of wound healing and voice outcomes. However, depth and extent of the lesion created to study wound healing in animal models vary across studies, likely contributing to different outcomes. Our goal was to create a surgery classification system to enable comparison of postoperative outcomes across animal vocal fold wound-healing studies. STUDY
designProspective, controlled animal study.
methodsRats underwent one of three types of unilateral vocal fold surgeries classified by depth and length of resection. The surgeries were: for subepithelial injury, resection of epithelium and superficial layer of the lamina propria at the midmembranous portion of the vocal fold; for transmucosal injury, resection of epithelium and lamina propria; and for transmuscular injury, resection of epithelium, lamina propria, and superficial portion of the vocalis muscle. Wound healing was evaluated histologically at various time points up to 35 days postinjury.
resultsComplete healing occurred by 14 days postsurgery for subepithelial injury, and by day 35 for transmucosal injury. Injury remained present at day 35 for transmuscular injury.
conclusionsTiming and completeness of healing varied by extent and depth of resection. Scarless healing occurred rapidly following subepithelial injury, whereas scarring was observed at 5 weeks after transmuscular injury. The proposed classification system may facilitate comparison of surgical outcomes across vocal fold wound-healing studies. LEVELS OF EVIDENCE: N/A.
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