Evidence map›Paper›PMID 24965898›Full record

ArticleAbdominal imaging2015

Automated volumetric analysis for comparison of oral sulfate solution (SUPREP) with established cathartic agents at CT colonography.

Peter Bannas, Joshua Bakke, James L Patrick, Perry J Pickhardt

Erratum issued Registry-linked trialAbstract readComparative Study
In one paragraph

Article in Abdominal imaging, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT02761213 (Efficacy of Reduced Volume Oral Sulfate Solution), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02761213 phase4completednot on this mapstarted 2016, after this paper: background citation

Efficacy of Reduced Volume Oral Sulfate Solution (SUPREP) Compared With PEG Plus Ascorbic Acid for Screening Colonoscopy: Single Center, Single Blinded Prospective Randomized Study

TypeinterventionalSponsorBo-In LeeRan2016 to 2017Enrolled200ConditionsCathartic ColonArmsOral sulfate solution (OSS), 2-L PEG/Asc
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

Peter BannasDepartment of Radiology, University of Wisconsin School of Medicine & Public Health, E3/311 Clinical Science Center, 600 Highland Ave., Madison, WI, 53792-3252, USA, pbannas@uwhealth.org.
Joshua Bakke
James L Patrick
Perry J Pickhardt
University of Wisconsin–Madison · US

Funding

Institutional Clinical and Translational Science AwardUL1TR000427 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2012 to 2016
$32.2M
Virtual Colonoscopy and Colorectal Cancer ScreeningR01CA144835 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI PICKHARDT, PERRY, SMITH, MAUREEN A · 2010 to 2013
$2.1M
Ultra-Low Radiation Dose Body CT ImagingR01CA169331 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI CHEN, GUANG-HONG, PICKHARDT, PERRY · 2012 to 2016
$1.4M
NCATS NIH HHS UL1 TR000427NCI NIH HHS 1R01CA144835-01NCI NIH HHS 1R01CA169331-01NCI NIH HHS R01 CA144835NCI NIH HHS R01 CA169331
6 · The paper itself

Abstract

purposeTo objectively compare residual colonic fluid volume and attenuation of oral sulfate solution (OSS) with four different established cathartic regimens using an automated volumetric software tool at CT colonography (CTC).

methodsThis HIPAA-compliant study had institutional review board approval. Volumetric analysis of residual contrast-tagged colonic fluid was performed on CTC studies in 263 adults (mean age 60.1 years; 137M/126F) using an automated volumetric software tool. Twenty-three patients receiving 177 mL OSS (SUPREP; single-bottle purgation) were compared with 60 patients each receiving 45 mL sodium phosphate (NaP), 90 mL NaP (2× NaP), 592 mL (two bottles) magnesium citrate (MgC), and 4,000 mL polyethylene glycol (PEG). All patients received oral contrast cleansing after catharsis. Data were analyzed with unpaired t test with Welch correction and F test.

resultsThe mean volume of residual colonic fluid was less with OSS (125 ± 60 mL) than for established cathartic agents: 2× NaP (206 ± 125 mL, P < 0.0001), MgC (184 ± 125 mL, P < 0.01), PEG (166 ± 114 mL, P < 0.05), and NaP (165 ± 135 mL, P = 0.067). Variance of volumes was also significantly lower for OSS (range 28-251 mL) than for established agents (range 4-853 mL) (all P < 0.01). Mean fluid attenuation was higher with OSS (956 ± 168 HU) than for established agents (all P < 0.05): 2× NaP (455 ± 191 HU), MgC (691 ± 154 HU), NaP (779 ± 127 HU), and PEG (843 ± 193 HU).

conclusionsAutomated volumetry allows rapid objective assessment of bowel preparation quality at CTC. Purgation with the novel oral sulfate solution (SUPREP) consistently resulted in less residual colonic fluid and higher fluid attenuation compared with established cathartic regimens.

Indexed as

CatharticsColonography, Computed TomographicSulfatesAdministration, OralAgedAged, 80 and overCitric AcidColonContrast MediaFemaleHumansMaleMiddle AgedOrganometallic CompoundsPhosphatesPolyethylene GlycolsCatharticsCitric AcidContrast Mediamagnesium citrateOrganometallic CompoundsPhosphatesPolyethylene Glycolssodium phosphateSulfates

Identifiers

PMID24965898
PMCPMC4545636
OpenAlexW2091846206

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.