ArticleBMC psychiatry2014
Pain, not chronic disease, is associated with the recurrence of depressive and anxiety disorders.
Article in BMC psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Effectiveness of balneotherapy in reducing pain, disability, and depression in patients with Fibromyalgia syndrome: a systematic review with meta-analysis.International journal of biometeorology · 2024Pooled it
- Risk factors for relapse and recurrence of depression in adults and how they operate: A four-phase systematic review and meta-synthesis.Clinical psychology review · 2018Pooled it
- Indicators of patients with major depressive disorder in need of highly specialized care: A systematic review.PloS one · 2017Pooled it
- Effect of esketamine on serum neurotransmitters in patients with postpartum depression: a randomized controlled trial.BMC anesthesiology · 2024Trial
- Health-Related Quality of Life in Cancer Survivors with Chemotherapy-Induced Peripheral Neuropathy: A Randomized Clinical Trial.The oncologist · 2021Trial
- Depression in patients with knee osteoarthritis: risk factors and associations with joint symptoms.BMC musculoskeletal disorders · 2021Trial
- Design Preferences for Mental Health Apps Among Nondigitally Native Adults With Chronic Pain: Qualitative Analysis.JMIR mHealth and uHealth · 2026Article
- Optimizing Usability of Digital Health Interventions for Nondigitally Native Adults: A Framework-Based Approach to Develop Just-in-Time Adaptive Interventions (JITAIs) and Other Adaptations.JMIR human factors · 2026Article
- The association between health-related quality of life and the meaning of life in community-dwelling older adults.BMC geriatrics · 2026Article
- How pain intensity and mental disorders shape chronic pain sick leave and quality of life in the general Spanish population.Scientific reports · 2026Article
- The influence of oral health on sports performance: an interdisciplinary perspective.British dental journal · 2026Review
- Association between functional gastrointestinal disorders and Parkinson's disease in a prospective cohort study.NPJ Parkinson's disease · 2025Article
- Article
- Two in one: a randomized controlled trial on an internet-based intervention (Lenio) for management of both chronic pain and depressive symptoms.Frontiers in psychiatry · 2025Article
- The mediating role of anxiety and depression in the relationship between alexithymia, somatosensory amplification, and functional impairment in fibromyalgia.Frontiers in psychiatry · 2025Article
- Longitudinal relationship between adverse childhood experiences and depressive symptoms: the mediating role of physical pain.BMC psychiatry · 2024Article
- Daytime napping and the incidence of Parkinson's disease: a prospective cohort study with Mendelian randomization.BMC medicine · 2024Article
- The impact of exercise intensity on depression in fibromyalgia: a randomized controlled trial.Frontiers in psychology · 2024Article
- Protective and Risk Factors at the Intersection of Chronic Pain, Depression, Anxiety, and Somatic Amplification: A Latent Profile Approach.Journal of pain research · 2022Article
- Comorbid Chronic Pain and Depression: Shared Risk Factors and Differential Antidepressant Effectiveness.Frontiers in psychiatry · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStudies suggest that poor physical health might be associated with increased depression and anxiety recurrence. The objectives of this study were to determine whether specific chronic diseases and pain characteristics are associated with depression and anxiety recurrence and to examine whether such associations are mediated by subthreshold depressive or anxiety symptoms.
methods1122 individuals with remitted depressive or anxiety disorder (Netherlands Study of Depression and Anxiety) were followed up for a period of four years. The impact of specific chronic diseases and pain characteristics on recurrence was assessed using Cox regression and mediation analyses.
resultsChronic diseases were not associated with recurrence. Neck (HR 1.45, p < .01), chest (HR 1.65, p < .01), abdominal (HR 1.52, p < .01) pain, an increase in the number of pain locations (HR 1.10, p < .01) and pain severity (HR 1.18, p = .01) were associated with an increased risk of depression recurrence but not anxiety. Subthreshold depressive symptoms mediated the associations between pain and depression recurrence.
conclusionsPain, not chronic disease, increases the likelihood of depression recurrence, largely through its association with aggravated subthreshold depressive symptoms. These findings support the idea of the existence of a mutually reinforcing mechanism between pain and depression and are indicative of the importance of shedding light on neurobiological links in order to optimize pain and depression management.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.