ArticleInternational journal of rheumatic diseases2016
In vivo quantification of mouse autoimmune arthritis by PET/CT.
Article in International journal of rheumatic diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 17 citations in OpenAlex.
- Quantitative tracking of inflammatory activity at the peak and trough plasma levels of tofacitinib, a Janus kinase inhibitor, via in vivoInternational journal of rheumatic diseases · 2019Article
- A model of chronic enthesitis and new bone formation characterized by multimodal imaging.Disease models & mechanisms · 2018Article
- Development of an Ultra High Resolution PET Scanner for Imaging Rodent Paws: PawPET.IEEE transactions on radiation and plasma medical sciences · 2018Article
- In-vivo quantitative assessment of the therapeutic response in a mouse model of collagen-induced arthritis usingClinical and experimental immunology · 2017Article
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Authors and funding
5 authors at 2 institutions in 1 country.
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Abstract
aimTo quantify the progression and severity of mouse collagen-induced arthritis (CIA) using an in vivo imaging tool, (18) F-fluorodeoxyglucose ((18) F-FDG) PET/CT and validate it against gold standard 'histopathological' evaluation.
methodThe PET radiotracer (18) F-FDG, a marker for glucose metabolism, was injected in mice at different stages of CIA and the radiotracer distribution was imaged using a PET scanner. A sequential CT scan provided correlated anatomy. Radiotracer concentration was derived from PET/CT images for individual limb joints and on a per-limb basis at different stages of the disease. The imaging outcomes were subjected to correlation analysis with concurrently measured clinical and histological score.
resultsClinical and histological score, and hence disease severity, showed a strong linear correlation (r(2) = 0.71, P = 0.001 and r(2) = 0.87, P < 0.001, respectively) with radiotracer concentration measured from PET/CT during the progression of CIA.
conclusionsThe strong positive correlation of the (18) F-FDG PET/CT findings with the histopathological evaluation at different stages of the disease suggest the potential of this imaging tool for the non-invasive assessment of progression and severity in mouse autoimmune arthritis. Thus, in preclinical studies, (18) F-FDG PET/CT can be considered as a non-invasive tool to develop novel therapies of inflammatory arthritis.
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