ArticleJournal of tissue engineering and regenerative medicine2017
Scaffold-free cartilage subjected to frictional shear stress demonstrates damage by cracking and surface peeling.
Article in Journal of tissue engineering and regenerative medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Nanomaterials in Drug Delivery: Strengths and Opportunities in Medicine.Molecules (Basel, Switzerland) · 2024Review
- The application and progress of tissue engineering and biomaterial scaffolds for total auricular reconstruction in microtia.Frontiers in bioengineering and biotechnology · 2023Review
- Additively Manufactured Multi-Morphology Bone-like Porous Scaffolds: Experiments and Micro-Computed Tomography-Based Finite Element Modeling Approaches.International journal of bioprinting · 2022Article
- Impact of different physical activity types on knee joint structural degeneration assessed with 3-T MRI in overweight and obese subjects: data from the osteoarthritis initiative.Skeletal radiology · 2021Article
- Influence of the Mechanical Environment on the Regeneration of Osteochondral Defects.Frontiers in bioengineering and biotechnology · 2021Review
- The tribology of cartilage: Mechanisms, experimental techniques, and relevance to translational tissue engineering.Clinical biomechanics (Bristol, Avon) · 2020Review
- Apparatus and Method for Rapid Detection of Acoustic Anisotropy in Cartilage.Journal of medical and biological engineering · 2020Article
- High-Throughput, Temporal and Dose Dependent, Effect of Vitamins and Minerals on Chondrogenesis.Frontiers in cell and developmental biology · 2020Article
- Rapid Detection of Shear-Induced Damage in Tissue-Engineered Cartilage Using Ultrasound.Tissue engineering. Part C, Methods · 2018Article
- Simple geometry tribological study of osteochondral graft implantation in the knee.Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine · 2018Article
- Thyroxine Increases Collagen Type II Expression and Accumulation in Scaffold-Free Tissue-Engineered Articular Cartilage.Tissue engineering. Part A · 2018Article
- A review of using green chemistry methods for biomaterials in tissue engineering.International journal of nanomedicine · 2018Review
- Nondestructive Techniques to Evaluate the Characteristics and Development of Engineered Cartilage.Annals of biomedical engineering · 2016Review
- Ultrasound Elastography for Estimation of Regional Strain of Multilayered Hydrogels and Tissue-Engineered Cartilage.Annals of biomedical engineering · 2015Article
- Review of the biomechanics and biotribology of osteochondral grafts used for surgical interventions in the knee.Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine · 2015Review
- Coefficient of Friction Patterns Can Identify Damage in Native and Engineered Cartilage Subjected to Frictional-Shear Stress.Annals of biomedical engineering · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Scaffold-free engineered cartilage is being explored as a treatment for osteoarthritis. In this study, frictional shear stress was applied to determine the friction and damage behaviour of scaffold-free engineered cartilage, and tissue composition was investigated as it related to damage. Scaffold-free engineered cartilage frictional shear stress was found to exhibit a time-varying response similar to that of native cartilage. However, damage occurred that was not seen in native cartilage, manifesting primarily as tearing through the central plane of the constructs. In engineered cartilage, cells occupied a significantly larger portion of the tissue in the central region where damage was most prominent (18 ± 3% of tissue was comprised of cells in the central region vs 5 ± 1% in the peripheral region; p < 0.0001). In native cartilage, cells comprised 1-4% of tissue for all regions. Average bulk cellularity of engineered cartilage was also greater (68 × 10
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.