ArticleBMC bioinformatics2014
Identification and phylogenetic analyses of VASt, an uncharacterized protein domain associated with lipid-binding domains in Eukaryotes.
Article in BMC bioinformatics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Sterol binding mechanism of a plant START-like domain: A new sterol transport paradigm via an amphiphilic cavity.The FEBS journal · 2026Article
- A bridge-like lipid transfer protein is critical for generation of invasive stages in malaria parasites.Nature communications · 2026Article
- An origin for a eukaryotic lipid transfer protein fold in Asgard archaea.bioRxiv : the preprint server for biology · 2025Article
- Enhanced drought and salt stress tolerance in Arabidopsis via ectopic expression of the PvMLP19 gene.Plant cell reports · 2025Article
- Impact of Alignments on the Accuracy of Protein Subcellular Localization Predictions.Proteins · 2025Article
- Article
- A VASt-domain protein regulates autophagy, membrane tension, and sterol homeostasis in rice blast fungus.Autophagy · 2021Article
- Courier service for phosphatidylinositol: PITPs deliver on demand.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2021Review
- Sterol biosensor reveals LAM-family Ltc1-dependent sterol flow to endosomes upon Arp2/3 inhibition.The Journal of cell biology · 2020Article
- Patterns of Sequence and Expression Diversification Associate Members of theFrontiers in genetics · 2020Article
- The cholesterol transfer protein GRAMD1A regulates autophagosome biogenesis.Nature chemical biology · 2019Article
- The Expanding and Unexpected Functions of Mitochondria Contact Sites.Trends in cell biology · 2019Review
- Article
- Lipid transfer proteins rectify inter-organelle flux and accurately deliver lipids at membrane contact sites.Journal of lipid research · 2018Review
- Structural basis of sterol binding and transport by a yeast StARkin domain.The Journal of biological chemistry · 2018Article
- Advances on the Transfer of Lipids by Lipid Transfer Proteins.Trends in biochemical sciences · 2017Review
- Article
- Ltc1 is an ER-localized sterol transporter and a component of ER-mitochondria and ER-vacuole contacts.The Journal of cell biology · 2015Article
- The origin and evolution of ribonucleotide reduction.Life (Basel, Switzerland) · 2015Review
- Profiling the LAM Family of Contact Site Tethers Provides Insights into Their Regulation and Function.Contact (Thousand Oaks (Ventura County, Calif.))Article
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Authors and funding
4 authors.
Funding
Abstract
backgroundSeveral regulators of programmed cell death (PCD) in plants encode proteins with putative lipid-binding domains. Among them, VAD1 is a regulator of PCD propagation harboring a GRAM putative lipid-binding domain. However the function of VAD1 at the subcellular level is unknown and the domain architecture of VAD1 has not been analyzed in details.
resultsWe analyzed sequence conservation across the plant kingdom in the VAD1 protein and identified an uncharacterized VASt (VAD1 Analog of StAR-related lipid transfer) domain. Using profile hidden Markov models (profile HMMs) and phylogenetic analysis we found that this domain is conserved among eukaryotes and generally associates with various lipid-binding domains. Proteins containing both a GRAM and a VASt domain include notably the yeast Ysp2 cell death regulator and numerous uncharacterized proteins. Using structure-based phylogeny, we found that the VASt domain is structurally related to Bet v1-like domains.
conclusionWe identified a novel protein domain ubiquitous in Eukaryotic genomes and belonging to the Bet v1-like superfamily. Our findings open perspectives for the functional analysis of VASt-containing proteins and the characterization of novel mechanisms regulating PCD.
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