Evidence map›Paper›PMID 24965218›Full record

Trial reportBMC oral health2014

Effect of nonsurgical periodontal therapy verses oral hygiene instructions on type 2 diabetes subjects with chronic periodontitis: a randomised clinical trial.

Renukanth Patabi Cheta Raman, Tara Bai Taiyeb-Ali, Siew Pheng Chan, Karuthan Chinna, Rathna Devi Vaithilingam

Registry-linked trialOpen access · goldAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC oral health, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01951547 (The Effect of Non-surgical Periodontal Therapy on Host Response and Microbiological Profile of Type 2 Diabetics With Periodontal Disease.), which is not on this map. Cited by 24 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 10 pooled it
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01951547 nacompletednot on this map

The Effect of Non-surgical Periodontal Therapy on Host Response and Microbiological Profile of Type 2 Diabetics With Periodontal Disease.

TypeinterventionalSponsorUniversity of MalayaRan2010 to 2011Enrolled40ConditionsChronic Periodontitis, Type 2 DiabetesArmsNonsurgical periodontal therapy, Oral hygiene instructions
3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 10 syntheses or guidelines pooled it, 56 citations in OpenAlex.

  1. Pooled it
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  11. Trial
  12. Review
  13. Nonsurgical Periodontal Therapy for Diabetes Patients with Periodontal Disease.Journal of clinical and experimental dentistry · 2026
    Review
  14. Article
  15. Article
  16. Article
  17. Oral Health Status of Hospitalized Patients With Type 2 Diabetes.Diabetes spectrum : a publication of the American Diabetes Association · 2020
    Article
  18. Metabolic syndrome and periodontal disease: An overview for physicians.Journal of family medicine and primary care · 2019
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Renukanth Patabi Cheta Raman
Tara Bai Taiyeb-Ali
Siew Pheng Chan
Karuthan Chinna
Rathna Devi VaithilingamDepartment of Restorative Dentistry, Faculty of Dentistry, University of Malaya, 50603 Kuala Lumpur, Malaysia. rathna@um.edu.my.
University of Malaya · MY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background40 subjects with type 2 diabetes and moderate to severe CP were randomly distributed to groups receiving either NSPT or OHI. Periodontal parameters, glycosylated haemoglobin (HbA1c) and high-sensitivity C-reactive protein (hs-CRP) were evaluated at baseline, 2- and 3-months intervals.

methods40 subjects with type 2 diabetes and moderate to severe CP were randomly distributed to groups receiving either NSPT or OHI. Periodontal parameters, glycosylated haemoglobin (HbA1c) and high-sensitivity C-reactive protein (hs-CRP) were evaluated at baseline, 2- and 3-months intervals.

results15 subjects from NSPT group and 17 from OHI group completed the study. The difference in plaque index (PI) between NSPT and OHI groups were significant at 2 months recall (p = 0.013). There was no significant difference between NSPT and OHI group for all other clinical periodontal parameters, HbA1c and CRP levels. At 3 months post-therapy, periodontal parameters improved significantly in both groups with sites with probing pocket depth (PPD) < 4 mm reported as 98 ± 1.8% in NSPT group and 92 ± 14.9% in OHI group. Mean PPD and mean probing attachment loss (PAL) within the NSPT group reduced significantly from baseline (2.56 ± 0.57 mm, 3.35 ± 0.83 mm) to final visit (1.94 ± 0.26 mm, 2.92 ± 0.72 mm) (p = 0.003, p < 0.001). For OHI group, improvements in mean PPD and mean PAL were also seen from baseline (2.29 ± 0.69 mm, 2.79 ± 0.96 mm) to final visit (2.09 ± 0.72 mm, 2.62 ± 0.97 mm) (p < 0.001 for both). Similarly, HbA1c levels decreased in both groups with NSPT group recording statistically significant reduction (p = 0.038). Participants who demonstrated ≥ 50% reduction in PPD showed significant reductions of HbA1c and hs-CRP levels (p = 0.004 and p = 0.012).

conclusionNSPT significantly reduced PI at 2 months post-therapy as compared to OHI. Both NSPT and OHI demonstrated improvements in other clinical parameters as well as HbA1c and CRP levels.

trial registrationClinicalTrials.gov: NCT01951547.

Indexed as

AdultAgedAnti-Infective Agents, LocalChlorhexidineChronic PeriodontitisC-Reactive ProteinDental Devices, Home CareDental Plaque IndexDental ScalingDiabetes Mellitus, Type 2FemaleFollow-Up StudiesGlycated HemoglobinHumansMaleMiddle AgedAnti-Infective Agents, LocalChlorhexidineC-Reactive ProteinGlycated HemoglobinMouthwashes

Identifiers

PMID24965218
PMCPMC4082680
OpenAlexW1980583542

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.