Evidence map›Paper›PMID 24965217›Full record

ReviewMycopathologia2014

Fungal endocarditis observed over an 8-year period and a review of the literature.

Spinello Antinori, Laurenzia Ferraris, Giovanna Orlando, Loredana Tocalli, Davide Ricaboni, Mario Corbellino, Salvatore Sollima, Massimo Galli, Laura Milazzo

Abstract readReview
PubMed Publisher
In one paragraph

Review in Mycopathologia, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.

  1. Pooled it
  2. Impact ofMolecular imaging and radionuclide therapy · 2026
    Article
  3. Synergistic eradication ofFrontiers in medicine · 2026
    Article
  4. Article
  5. Epidemiology, Risk Factors and Clinical Outcome of Candidaemia:Sultan Qaboos University medical journal · 2025
    Observational
  6. Favourable outcome ofSouthern African journal of infectious diseases · 2025
    Article
  7. Le infezioni in medicina · 2025
    Article
  8. Article
  9. Article
  10. Review
  11. First case report ofFrontiers in cardiovascular medicine · 2023
    Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Fatal Prosthetic Valve Endocarditis Due toInfection and drug resistance · 2020
    Article
  18. Recurrent Endocarditis in Persons Who Inject Drugs.Open forum infectious diseases · 2019
    Article
  19. Medical mycology case reports · 2019
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Spinello Antinori3rd Division of Infectious Diseases, Luigi Sacco Department of Biomedical and Clinical Sciences, University of Milan, Via GB Grassi 74, 20157, Milan, Italy, spinello.antinori@unimi.it.
Laurenzia Ferraris
Giovanna Orlando
Loredana Tocalli
Davide Ricaboni
Mario Corbellino
Salvatore Sollima
Massimo Galli
Laura Milazzo
Luigi Sacco Hospital · ITUniversity of Milan · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFungal endocarditis (FE) is a "modern" disease that is considered an emerging cause of infective endocarditis (IE). The most frequently identified fungal pathogens are Candida spp., which are responsible for up to two-thirds of all cases; the remaining cases are due to Aspergillus spp., Histoplasma capsulatum or, more rarely, other yeasts and moulds.

objectivesTo describe the prevalence, clinical characteristics and outcome of FE diagnosed in a single tertiary centre and review the literature concerning FE. DESIGN AND

settingAn 8-year retrospective review of the case records of patients attending a single Italian University Centre and diagnosed as having definite or probable IE as defined by the modified Duke criteria.

resultsSix patients were identified from 229 episodes of IE: five cases involved a prosthetic valve, and one a native valve of an intravenous drug user. Five cases were caused by Candida spp. (two by C. albicans, one each by C. lusitaniae, C. dubliniensis and C. glabrata) and one by Aspergillus flavus. Three patients were treated by means of surgery plus antifungal therapy; two received antifungal therapy alone. Three patients survived, but only the patient with Aspergillus endocarditis was followed up for a long time.

conclusionsFE is difficult to diagnose but generally associated with healthcare infections. The optimal treatment is poorly characterised, and international collaborative studies are urgently needed to evaluate newer antifungal agents.

Indexed as

Antifungal AgentsEndocarditisFungiHumansItalyMycosesPrevalenceSurgical Procedures, OperativeSurvival AnalysisTertiary Care CentersTreatment OutcomeAntifungal Agents

Identifiers

PMID24965217
OpenAlexW2033739597

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.