ArticleBMC systems biology2014
Analyzing networks of phenotypes in complex diseases: methodology and applications in COPD.
Article in BMC systems biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Personalized respiratory medicine: exploring the horizon, addressing the issues. Summary of a BRN-AJRCCM workshop held in Barcelona on June 12, 2014.American journal of respiratory and critical care medicine · 2015Pooled it
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- A novel phenotype imputation method with copula model.BMC bioinformatics · 2024Article
- Current and future directions in network biology.Bioinformatics advances · 2024Article
- Networks as Biomarkers: Uses and Purposes.Genes · 2023Review
- Molecular networks in Network Medicine: Development and applications.Wiley interdisciplinary reviews. Systems biology and medicine · 2020Review
- Joint analysis of multiple phenotypes using a clustering linear combination method based on hierarchical clustering.Genetic epidemiology · 2020Article
- Testing gene-environment interactions for rare and/or common variants in sequencing association studies.PloS one · 2020Article
- Phenotypes in Behçet's syndrome.Internal and emergency medicine · 2019Review
- Precision Medicine.Circulation research · 2019Article
- A Network Analysis of Biomarkers for Type 2 Diabetes.Diabetes · 2019Article
- Test Gene-Environment Interactions for Multiple Traits in Sequencing Association Studies.Human heredity · 2019Article
- A gene based approach to test genetic association based on an optimally weighted combination of multiple traits.PloS one · 2019Article
- A hierarchical clustering method for dimension reduction in joint analysis of multiple phenotypes.Genetic epidemiology · 2018Article
- Testing an optimally weighted combination of common and/or rare variants with multiple traits.PloS one · 2018Article
- COPD: time to improve its taxonomy?ERJ open research · 2018Article
- An Adaptive Fisher's Combination Method for Joint Analysis of Multiple Phenotypes in Association Studies.Scientific reports · 2016Article
- Identification of Gene Networks for Residual Feed Intake in Angus Cattle Using Genomic Prediction and RNA-seq.PloS one · 2016Article
- From big data analysis to personalized medicine for all: challenges and opportunities.BMC medical genomics · 2015Review
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundThe investigation of complex disease heterogeneity has been challenging. Here, we introduce a network-based approach, using partial correlations, that analyzes the relationships among multiple disease-related phenotypes.
resultsWe applied this method to two large, well-characterized studies of chronic obstructive pulmonary disease (COPD). We also examined the associations between these COPD phenotypic networks and other factors, including case-control status, disease severity, and genetic variants. Using these phenotypic networks, we have detected novel relationships between phenotypes that would not have been observed using traditional epidemiological approaches.
conclusionPhenotypic network analysis of complex diseases could provide novel insights into disease susceptibility, disease severity, and genetic mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.