ArticleNature communications2014
Development of oculomotor circuitry independent of hox3 genes.
Article in Nature communications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Gene Identification for Ocular Congenital Cranial Motor Neuron Disorders Using Human Sequencing, Zebrafish Screening, and Protein Binding Microarrays.Investigative ophthalmology & visual science · 2025Article
- Subsets of extraocular motoneurons produce kinematically distinct saccades during hunting and exploration.Current biology : CB · 2025Article
- Long non-coding RNA HOXA-AS3 facilitates the malignancy in colorectal cancer by miR-4319/SPNS2 axis.Journal of physiology and biochemistry · 2021Article
- A distributed saccade-associated network encodes high velocity conjugate and monocular eye movements in the zebrafish hindbrain.Scientific reports · 2021Article
- Development and migration of the zebrafish rhombencephalic octavolateral efferent neurons.The Journal of comparative neurology · 2021Article
- Association of the Epithelial-Mesenchymal Transition (EMT) with Cisplatin Resistance.International journal of molecular sciences · 2020Review
- LncRNA HOXA-AS3 confers cisplatin resistance by interacting with HOXA3 in non-small-cell lung carcinoma cells.Oncogenesis · 2019Article
- Whole-Brain Calcium Imaging during Physiological Vestibular Stimulation in Larval Zebrafish.Current biology : CB · 2018Article
- Electron Microscopic Reconstruction of Functionally Identified Cells in a Neural Integrator.Current biology : CB · 2017Article
- Key Features of Structural and Functional Organization of Zebrafish Facial Motor Neurons Are Resilient to Disruption of Neuronal Migration.Current biology : CB · 2017Article
- Extraocular motoneuron pools develop along a dorsoventral axis in zebrafish, Danio rerio.The Journal of comparative neurology · 2017Article
- Sustained Rhythmic Brain Activity Underlies Visual Motion Perception in Zebrafish.Cell reports · 2016Article
- Development of functional hindbrain oculomotor circuitry independent of both vascularization and neuronal activity in larval zebrafish.Current neurobiology · 2016Article
- Saccadic and Postsaccadic Disconjugacy in Zebrafish Larvae Suggests Independent Eye Movement Control.Frontiers in systems neuroscience · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Hox genes have been shown to be essential in vertebrate neural circuit formation and their depletion has resulted in homeotic transformations with neuron loss and miswiring. Here we quantifiy four eye movements in the zebrafish mutant valentino and hox3 knockdowns, and find that contrary to the classical model, oculomotor circuits in hindbrain rhombomeres 5-6 develop and function independently of hox3 genes. All subgroups of oculomotor neurons are present, as well as their input and output connections. Ectopic connections are also established, targeting two specific subsets of horizontal neurons, and the resultant novel eye movements coexists with baseline behaviours. We conclude that the high expression of hox3 genes in rhombomeres 5-6 serves to prevent aberrant neuronal identity and behaviours, but does not appear to be necessary for a comprehensive assembly of functional oculomotor circuits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.