ArticlePloS one2014
Fluoride increases superoxide production and impairs the respiratory chain in ROS 17/2.8 osteoblastic cells.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 45 citations in OpenAlex.
- Amelioration of Fluoride Induced Toxicity by trans-Chalcone in Zebrafish Larvae and Its Gill Cell Line: An In Vivo and In Vitro Approach.Environmental toxicology · 2026Article
- Yerba Mate and Bone Health: Can Antioxidant Capacity Influence Skeletal Outcomes?Journal of bone metabolism · 2026Article
- Fluoride-Induced Mitochondrial Dysfunction and Approaches for Its Intervention.Biological trace element research · 2024Review
- Microstructural Analysis of Cancellous Bone in Fluorosis Rats.Biological trace element research · 2023Article
- Fluoride Exposure Provokes Mitochondria-Mediated Apoptosis and Increases Mitophagy in Osteocytes via Increasing ROS Production.Biological trace element research · 2023Article
- The Strong Protective Action of CeNanomaterials (Basel, Switzerland) · 2022Article
- Intrauterine and Postnatal Exposure to High Levels of Fluoride Is Associated with Motor Impairments, Oxidative Stress, and Morphological Damage in the Cerebellum of Offspring Rats.International journal of molecular sciences · 2022Article
- Overlying water fluoride concentrations influence dissolved organic matter composition and migration from pore water in sediment via bacterial mechanisms.Environmental science and ecotechnology · 2022Article
- Sodium fluoride induces skeletal muscle atrophy via changes in mitochondrial and sarcomeric proteomes.PloS one · 2022Article
- Effect of Fluoride on Cytotoxicity Involved in Mitochondrial Dysfunction: A Review of Mechanism.Frontiers in veterinary science · 2022Review
- Article
- Astaxanthin Decreases Spatial Memory and Glutamate Transport Impairment Induced by Fluoride.Iranian journal of pharmaceutical research : IJPR · 2021Article
- Gastrodin alleviates bone damage by modulating protein expression and tissue redox state.FEBS open bio · 2020Article
- Principles of fluoride toxicity and the cellular response: a review.Archives of toxicology · 2020Review
- Genome-Wide Identification of Genes Involved in General Acid Stress and Fluoride Toxicity inFrontiers in microbiology · 2020Article
- Acute fluoride exposure alters myocardial redox and inflammatory markers in rats.Molecular biology reports · 2019Article
- Nitrate and Phosphate Transporters Rescue Fluoride Toxicity in Yeast.Chemical research in toxicology · 2019Article
- Exposure of Fluoride with Streptozotocin-Induced Diabetes Aggravates Testicular Damage and Spermatozoa Parameters in Mice.Journal of toxicology · 2019Article
- Black Tea Source, Production, and Consumption: Assessment of Health Risks of Fluoride Intake in New Zealand.Journal of environmental and public health · 2017Article
- The trypanocidal benznidazole promotes adaptive response to oxidative injury: Involvement of the nuclear factor-erythroid 2-related factor-2 (Nrf2) and multidrug resistance associated protein 2 (MRP2).Toxicology and applied pharmacology · 2016Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is known that fluoride produces oxidative stress. Inflammation in bone tissue and an impairment of the respiratory chain of liver have been described in treatments with fluoride. Whether the impairment of the respiratory chain and oxidative stress are related is not known. The aim of this work was to study the effects of fluoride on the production of superoxide radical, the function of the respiratory chain and the increase in oxidative stress in ROS 17/2.8 osteoblastic cells. We measured the effect of fluoride (100 µM) on superoxide production, oxygen consumption, lipid peroxidation and antioxidant enzymes activities of cultured cells following the treatment with fluoride. Fluoride decreased oxygen consumption and increased superoxide production immediately after its addition. Furthermore, chronic treatment with fluoride increased oxidative stress status in osteoblastic cells. These results indicate that fluoride could damage bone tissue by inhibiting the respiratory chain, increasing the production of superoxide radicals and thus of the others reactive oxygen species.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.