Evidence map›Paper›PMID 24964097›Full record

ArticleJournal of magnetic resonance imaging : JMRI2015

Measurements of wall shear stress and aortic pulse wave velocity in swine with familial hypercholesterolemia.

Andrew L Wentland, Oliver Wieben, Dhanansayan Shanmuganayagam, Christian G Krueger, Jennifer J Meudt, Daniel Consigny, Leonardo Rivera, Patrick E McBride, Jess D Reed, Thomas M Grist

Abstract read
In one paragraph

Article in Journal of magnetic resonance imaging : JMRI, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Pulmonary 4D-flow MRI imaging in landrace pigs under rest and stress.The international journal of cardiovascular imaging · 2024
    Article
  3. Abdominal applications of quantitative 4D flow MRI.Abdominal radiology (New York) · 2022
    Review
  4. Mechanosignals in abdominal aortic aneurysms.Frontiers in cardiovascular medicine · 2022
    Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Andrew L WentlandDepartment of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA; Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Oliver Wieben
Dhanansayan Shanmuganayagam
Christian G Krueger
Jennifer J Meudt
Daniel Consigny
Leonardo Rivera
Patrick E McBride
Jess D Reed
Thomas M Grist
University of Wisconsin–Madison · US

Funding

INTEGRATED TRAINING FOR PHYSICIAN-SCIENTISTST32GM008692 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI BURKARD, MARK E · 1998 to 2020
$10.3M
MR Biomarkers for the Noninvasive Evaluation & Early Detection of AtherosclerosisF30HL108539 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI WENTLAND, ANDREW L · 2011 to 2014
$139k
NHLBI NIH HHS F30 HL108539NHLBI NIH HHS F30 HL108539-02NIGMS NIH HHS T32 GM008692
6 · The paper itself

Abstract

purposeTo assess measurements of pulse wave velocity (PWV) and wall shear stress (WSS) in a swine model of atherosclerosis. MATERIALS AND

methodsNine familial hypercholesterolemic (FH) swine with angioplasty balloon catheter-induced atherosclerotic lesions to the abdominal aorta (injured group) and 10 uninjured FH swine were evaluated with a 4D phase contrast (PC) magnetic resonance imaging (MRI) acquisition, as well as with radial and Cartesian 2D PC acquisitions, on a 3T MR scanner. PWV values were computed from the 2D and 4D PC techniques, compared between the injured and uninjured swine, and validated against reference standard pressure probe-based PWV measurements. WSS values were also computed from the 4D PC MRI technique and compared between injured and uninjured groups.

resultsPWV values were significantly greater in the injured than in the uninjured groups with the 4D PC MRI technique (P = 0.03) and pressure probes (P = 0.02). No significant differences were found in PWV between groups using the 2D PC techniques (P = 0.75-0.83). No significant differences were found for WSS values between the injured and uninjured groups.

conclusionThe 4D PC MRI technique provides a promising means of evaluating PWV and WSS in a swine model of atherosclerosis, providing a potential platform for developing the technique for the early detection of atherosclerosis.

Indexed as

Pulse Wave AnalysisShear StrengthAnimalsAortaArterial PressureAtherosclerosisBlood Flow VelocityFemaleHyperlipoproteinemia Type IIImaging, Three-DimensionalMagnetic Resonance AngiographyMaleReproducibility of ResultsSensitivity and SpecificitySwine4D PC MRIatherosclerosisfamilial hypercholesterolemiapulse wave velocityPWVwall shear stress

Identifiers

PMID24964097
PMCPMC4276731
OpenAlexW2099733780

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.