ArticlePloS one2014
Estradiol increases mucus synthesis in bronchial epithelial cells.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
40 citing papers in PubMed, 78 citations in OpenAlex.
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- Addressing Sex as a Biological Variable in Preclinical Models of Lung Disease: An Official American Thoracic Society Research Statement.American journal of respiratory and critical care medicine · 2025Article
- To study the impact of COVID-19 on the epidemiological characteristics of allergic rhinitis based on local big data in China.Scientific reports · 2024Article
- Sex differences in airway disease: estrogen and airway surface liquid dynamics.Biology of sex differences · 2024Review
- Chinese expert consensus on the diagnosis, treatment, and management of asthma in women across life.Journal of thoracic disease · 2024Review
- Sleep apnea syndrome associated with gonadal hormone imbalance (Review).Biomedical reports · 2023Review
- Associations Between Reproductive Factors and the Risk of Adult-Onset Asthma: A Prospective Cohort Study of European Ancestry.Journal of general internal medicine · 2023Article
- Sex differences in vanadium inhalation effects in non-ciliated bronchiolar cells.Histology and histopathology · 2023Article
- Identification of Sex-Specific Genetic Polymorphisms Associated with Asthma in Middle-Aged and Older Canadian Adults: An Analysis of CLSA Data.Journal of asthma and allergy · 2023Article
- Hedgehog Signaling as a Therapeutic Target for Airway Remodeling and Inflammation in Allergic Asthma.Cells · 2022Article
- Hormonal Effects on Asthma, Rhinitis, and Eczema.The journal of allergy and clinical immunology. In practice · 2022Review
- Sex Plays a Multifaceted Role in Asthma Pathogenesis.Biomolecules · 2022Review
- Lung Function Variation during the Estrus Cycle of Mares Affected by Severe Asthma.Animals : an open access journal from MDPI · 2022Article
- Effects of the Sex Steroid Hormone Estradiol on Biofilm Growth of Cystic FibrosisFrontiers in cellular and infection microbiology · 2022Article
- Sex Disparities in Asthma Development and Clinical Outcomes: Implications for Treatment Strategies.Journal of asthma and allergy · 2022Review
- Anti-inflammatory, expectorant, and antitussive properties ofPharmaceutical biology · 2021Article
- Nonrespiratory Comorbidities in Asthma.The journal of allergy and clinical immunology. In practice · 2021Review
- Sex, Cells, and Asthma.Mayo Clinic proceedings · 2021Review
- Barrier Housing and Gender Effects on Allergic Airway Disease in a Murine House Dust Mite Model.ImmunoHorizons · 2021Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Airway epithelial mucus hypersecretion and mucus plugging are prominent pathologic features of chronic inflammatory conditions of the airway (e.g. asthma and cystic fibrosis) and in most of these conditions, women have worse prognosis compared with male patients. We thus investigated the effects of estradiol on mucus expression in primary normal human bronchial epithelial cells from female donors grown at an air liquid interface (ALI). Treatment with estradiol in physiological ranges for 2 weeks caused a concentration-dependent increase in the number of PAS-positive cells (confirmed to be goblet cells by MUC5AC immunostaining) in ALI cultures, and this action was attenuated by estrogen receptor beta (ER-β) antagonist. Protein microarray data showed that nuclear factor of activated T-cell (NFAT) in the nuclear fraction of NHBE cells was increased with estradiol treatment. Estradiol increased NFATc1 mRNA and protein in ALI cultures. In a human airway epithelial (1HAE0) cell line, NFATc1 was required for the regulation of MUC5AC mRNA and protein. Estradiol also induced post-translational modification of mucins by increasing total fucose residues and fucosyltransferase (FUT-4, -5, -6) mRNA expression. Together, these data indicate a novel mechanism by which estradiol increases mucus synthesis in the human bronchial epithelium.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.