ArticlePloS one2014
Rostro-caudal inhibition of hindlimb movements in the spinal cord of mice.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
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- Cerebrospinal fluid-contacting neurons: multimodal cells with diverse roles in the CNS.Nature reviews. Neuroscience · 2023Review
- Application of optogenetic glial cells to neuron-glial communication.Frontiers in cellular neuroscience · 2023Review
- Connecting the dots between cell populations, whole-brain activity, and behavior.Neurophotonics · 2022Article
- Stimulation of frontal pathways disrupts hand muscle control during object manipulation.Brain : a journal of neurology · 2022Article
- Anisotropic light scattering from myelinated axons in the spinal cord.Neurophotonics · 2020Article
- Article
- Spatiotemporal correlation of spinal network dynamics underlying spasms in chronic spinalized mice.eLife · 2017Article
- An Optogenetic Demonstration of Motor Modularity in the Mammalian Spinal Cord.Scientific reports · 2016Article
- Microfluidic device for the formation of optically excitable, three-dimensional, compartmentalized motor units.Science advances · 2016Article
- A Quasi-Likelihood Approach to Nonnegative Matrix Factorization.Neural computation · 2016Article
- Decoding the organization of spinal circuits that control locomotion.Nature reviews. Neuroscience · 2016Review
- Article
- Wirelessly powered, fully internal optogenetics for brain, spinal and peripheral circuits in mice.Nature methods · 2015Article
- Spinal primitives and intra-spinal micro-stimulation (ISMS) based prostheses: a neurobiological perspective on the "known unknowns" in ISMS and future prospects.Frontiers in neuroscience · 2015Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inhibitory neurons in the adult mammalian spinal cord are known to locally modulate afferent feedback--from muscle proprioceptors and from skin receptors--to pattern motor activity for locomotion and postural control. Here, using optogenetic tools, we explored how the same population of inhibitory interneurons globally affects hindlimb movements in the spinal cord of both anesthetized and freely moving mice. Activation of inhibitory interneurons up to the middle/lower spinal cord i.e. T8-T9, were able to completely and globally suppress all ipsilateral hindlimb movements. Furthermore, the same population of interneurons--which inhibited movements--did not significantly change the sensory and proprioceptive information from the affected limbs to the cortex. These results suggest a rostro-caudal organization of inhibition in the spinal cord motor output without modulation of ascending sensory pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.