ArticlePloS one2014
Skin fibroblasts from patients with type 1 diabetes (T1D) can be chemically transdifferentiated into insulin-expressing clusters: a transgene-free approach.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 21 citations in OpenAlex.
- Stem Cells Reprogramming in Diabetes Mellitus and Diabetic Complications: Recent Advances.Current diabetes reviews · 2025Review
- Direct Conversion of Human Urine Cells to Neurons by Small Molecules.Scientific reports · 2019Article
- RNA recombination at Chikungunya virus 3'UTR as an evolutionary mechanism that provides adaptability.PLoS pathogens · 2019Article
- Regenerative Medicine: Charting a New Course in Wound Healing.Advances in wound care · 2016Review
- CRISPR-on system for the activation of the endogenous human INS gene.Gene therapy · 2016Article
- Chemical transdifferentiation: closer to regenerative medicine.Frontiers of medicine · 2016Review
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
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Abstract
The conversion of differentiated cells into insulin-producing cells is a promising approach for the autologous replacement of pancreatic cells in patients with type 1 diabetes (T1D). At present, cellular reprogramming strategies encompass ethical problems, epigenetic failure or teratoma formation, which has prompted the development of new approaches. Here, we report a novel technique for the conversion of skin fibroblasts from T1D patients into insulin-expressing clusters using only drug-based induction. Our results demonstrate that skin fibroblasts from diabetic patients have pancreatic differentiation capacities and avoid the necessity of using transgenic strategies, stem cell sources or global demethylation steps. These findings open new possibilities for studying diabetes mechanisms, drug screenings and ultimately autologous transgenic-free regenerative medicine therapies in patients with T1D.
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