ArticleJournal of immunology research2014
Clinical course, prognosis, and cause of death in primary Sjögren's syndrome.
Article in Journal of immunology research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Pathogenesis-based treatments in primary Sjogren's syndrome using artificial intelligence and advanced machine learning techniques: a systematic literature review.Human vaccines & immunotherapeutics · 2018Pooled it
- Rate, risk factors and causes of mortality in patients with Sjögren's syndrome: a systematic review and meta-analysis of cohort studies.Rheumatology (Oxford, England) · 2016Pooled it
- Anatomy of a Cohort: 40-Year Follow-Up of a Sjögren's Cohort.Journal of clinical medicine · 2026Article
- Pulmonary Manifestations of Sjögren's Syndrome: A Case Report and Review of the Literature.Cureus · 2026Article
- Predicting major organ complications in primary Sjögren's disease using a machine learning ensemble strategy: a dual-center retrospective clinical study.Frontiers in immunology · 2026Article
- Article
- Epidemiology of Sjögren syndrome.Nature reviews. Rheumatology · 2024Review
- Mortality risk factors in primary Sjögren syndrome: a real-world, retrospective, cohort study.EClinicalMedicine · 2023Article
- Mortality associated with Sjögren's syndrome in the United States in the 1999-2020 period: A multiple cause-of-death study.Open medicine (Warsaw, Poland) · 2023Article
- Premature stroke and cardiovascular risk in primary Sjögren's syndrome.Frontiers in cardiovascular medicine · 2022Article
- Cardiovascular Events, Sleep Apnoea, and Pulmonary Hypertension in Primary Sjögren's Syndrome: Data from the French Health Insurance Database.Journal of clinical medicine · 2021Article
- Adropin Serum Levels in Patients with Primary Sjögren's Syndrome.Biomolecules · 2021Article
- Ten-year survival analysis of patients with primary Sjögren's syndrome in China: a national prospective cohort study.Therapeutic advances in musculoskeletal disease · 2021Article
- Characterization of a subset of patients with primary Sjögren's syndrome initially presenting with C3 or C4 hypocomplementemia.European journal of rheumatology · 2020Article
- Extraglandular ocular involvement and morbidity and mortality in primary Sjögren's Syndrome.PloS one · 2020Article
- Sex differences in pulmonary arterial hypertension: role of infection and autoimmunity in the pathogenesis of disease.Biology of sex differences · 2018Review
- Risk factors for primary Sjögren syndrome-associated interstitial lung disease.Journal of thoracic disease · 2018Article
- Increased risk of coronary heart disease among patients with primary Sjögren's syndrome: a nationwide population-based cohort study.Scientific reports · 2018Article
- Sjögren syndrome: what and where are we looking for?Current opinion in ophthalmology · 2015Review
- Sex differences in Sjögren's syndrome: a comprehensive review of immune mechanisms.Biology of sex differences · 2015Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this retrospective, single-centre study was to investigate the clinical and laboratory features and disease outcomes of 547 patients diagnosed with primary Sjögren's syndrome (pSS) between 1975 and 2010. The patients were followed up for 11.4±6.2 years. We evaluated the clinical and laboratory features, and assessed their influence on the time of diagnosis, survival, and mortality ratios, and compared them within subgroups defined by gender, glandular and extraglandular manifestations (EGMs), associated diseases, and immunoserological abnormalities. The most frequent EGMs were polyarthritis, Raynaud's phenomenon, and vasculitis among our patients; the most common associated disease was thyroiditis. During the follow-up period, 51 patients died; the median survival time was 33.71 years. Our results revealed a negative effect of cryoglobulinemia on survival ratios; additionally, the presence of vasculitis and lymphoproliferative diseases at the time of diagnosis increased the risk of mortality. The development of vasculitis was the most powerful predictor of mortality. Mortality in the group of patients with extraglandular symptoms was two- to threefold higher than in the glandular group. Attention is drawn to the importance of close monitoring and targeted diagnostic approaches in those pSS subgroups with obviously increased mortality risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.