Evidence map›Paper›PMID 24963496›Full record

ArticleJournal of immunology research2014

The feature of distribution and clonality of TCR γ/δ subfamilies T cells in patients with B-cell non-Hodgkin lymphoma.

Liang Wang, Meng Xu, Chunyan Wang, Lihua Zhu, Junyan Hu, Shaohua Chen, Xiuli Wu, Bo Li, Yangqiu Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
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  5. γδ T cells: origin and fate, subsets, diseases and immunotherapy.Signal transduction and targeted therapy · 2023
    Review
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  16. International journal of clinical and experimental pathology · 2018
    Article
  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Liang WangDepartment of Oncology, First Affiliated Hospital, Jinan University, Guangzhou 510632, China.ORCID 0000-0001-7915-9249
Meng XuDepartment of Oncology, First Affiliated Hospital, Jinan University, Guangzhou 510632, China.
Chunyan WangCentre of Oncology and Hematology, First Affiliated Hospital of Guangzhou Medical College, Guangzhou 510230, China.
Lihua ZhuDepartment of Rheumatism and Immunology, First Affiliated Hospital, Jinan University, Guangzhou 510632, China ; Institute of Hematology, Jinan University, Guangzhou 510632, China.
Junyan HuInstitute of Hematology, Jinan University, Guangzhou 510632, China.
Shaohua ChenInstitute of Hematology, Jinan University, Guangzhou 510632, China.
Xiuli WuInstitute of Hematology, Jinan University, Guangzhou 510632, China.
Bo LiInstitute of Hematology, Jinan University, Guangzhou 510632, China.
Yangqiu LiInstitute of Hematology, Jinan University, Guangzhou 510632, China ; Key Laboratory for Regenerative Medicine of Ministry of Education, Jinan University, Guangzhou 510632, China.
Jinan University · CNFirst Affiliated Hospital of Jinan University · CNFirst Affiliated Hospital of Guangzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Restricted T-cell receptor (TCR) Vα/Vβ repertoire expression and clonal expansion of αβ T cells especially for putative tumor-associated antigens were observed in patients with hematological malignancies. To further characterize the γδ T-cell immune status in B-cell non-Hodgkin lymphoma (B-NHL), we investigated the distribution and clonality of TCR Vγ/Vδ repertoire in peripheral blood (PB), bone marrow (BM), and lymph node (LN) from patients with B-NHL. Four newly diagnosed B-NHL cases, including three with diffuse large B-cell lymphoma (DLBCL) and one with small lymphocytic lymphoma (SLL), were enrolled. The restrictive expression of TCR Vγ/Vδ subfamilies with different distribution patterns could be detected in PB, BM, or LN from all of four patients, and partial subfamily T cells showed clonal proliferation. At least one clonally expanded Vδ subfamily member was found in PB from each patient. However, the expression pattern and clonality of TCR Vγ/Vδ changed in different immune organs and showed individual feature in different patients. The clonally expanded Vδ5, Vδ6, and Vδ8 were detected only in PB but neither in BM nor LN while clonally expanded Vδ2 and Vδ3 could be detected in both PB and BM/LN. In conclusion, the results provide a preliminary profile of distribution and clonality of TCR γ/δ subfamilies T cells in PB, BM, and LN from B-NHL; similar clonally expanded Vδ subfamily T cells in PB and BM may be related to the same B-cell lymphoma-associated antigens, while the different reactive clonally expanded Vγ/Vδ T cells may be due to local immune response.

Indexed as

AgedB-LymphocytesBone MarrowCell ProliferationClone CellsGene ExpressionHumansImmunophenotypingLeukemia, Lymphocytic, Chronic, B-CellLymph NodesLymphoma, Large B-Cell, DiffuseMaleMiddle AgedNeoplasm StagingReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, gamma-deltaReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, gamma-delta

Identifiers

PMID24963496
PMCPMC4055414
OpenAlexW2028767827

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.