Evidence map›Paper›PMID 24963487›Full record

Trial reportBioMed research international2014

Expression of serum exosomal microRNA-21 in human hepatocellular carcinoma.

Hongwei Wang, Lijuan Hou, Aihui Li, Yuxiu Duan, Haili Gao, Xinwen Song

Open access · hybridAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 191 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
191citing papers in PubMed, 3 pooled it
10.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

191 citing papers in PubMed, 3 syntheses or guidelines pooled it, 288 citations in OpenAlex.

  1. Pooled it
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  4. Review
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  6. Extracellular vesicles in viral disease management.Current research in microbial sciences · 2026
    Review
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  12. The diagnostic potential of extracellular vesicles in virus-related diseases.Frontiers in cellular and infection microbiology · 2025
    Review
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  18. Article
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131 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Hongwei WangDepartment of Infection Diseases, The First Affiliated Hospital of Xinxiang Medical University, Weihui 453100, China.
Lijuan HouDepartment of Infection Diseases, The First Affiliated Hospital of Xinxiang Medical University, Weihui 453100, China.
Aihui LiDepartment of Infection Diseases, The First Affiliated Hospital of Xinxiang Medical University, Weihui 453100, China.
Yuxiu DuanDepartment of Infection Diseases, The First Affiliated Hospital of Xinxiang Medical University, Weihui 453100, China.
Haili GaoDepartment of Infection Diseases, The First Affiliated Hospital of Xinxiang Medical University, Weihui 453100, China.
Xinwen SongDepartment of Infection Diseases, The First Affiliated Hospital of Xinxiang Medical University, Weihui 453100, China.
First Affiliated Hospital of Xinxiang Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

New strategies for the diagnosis of hepatocellular carcinoma (HCC) are urgently needed. There is an increasing interest in using microRNAs (miRNAs) as biomarkers in diseases. In this study, we examined the expression of miR-21 in serum exosomes from patients with HCC or chronic hepatitis B (CHB) and investigated the potential clinical significance of miR-21. Quantitative RT-PCR indicated that the concentration of miR-21 was significantly higher in exosomes than in exosome-depleted supernatants or the whole serum. Further, the expression level of serum exosomal miR-21 was significantly higher in patients with HCC than those with CHB or healthy volunteers (P < 0.0001, P < 0.0001, resp.). High level of miR-21 expression correlated with cirrhosis (P = 0.024) and advanced tumor stage (P = 0.001). Although serum level of miR-21 was higher in patients with HCC than in patients with CHB and healthy volunteers, the sensitivity of detection is much lower than using exosomal miR-21. These findings indicate that miR-21 is enriched in serum exosomes which provides increased sensitivity of detection than whole serum. Exosomal miR-21 may serve as a potential biomarker for HCC diagnosis.

Indexed as

Gene Expression Regulation, NeoplasticAgedAged, 80 and overBiomarkers, TumorCarcinoma, HepatocellularExosomesFemaleHepatitis B, ChronicHumansLiver NeoplasmsMaleMicroRNAsMiddle AgedRNA, NeoplasmBiomarkers, TumorMicroRNAsMIRN21 microRNA, humanRNA, Neoplasm

Identifiers

PMID24963487
PMCPMC4052145
OpenAlexW2135686606

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.