ArticleJournal of aging research2014
Redundant vasodilator pathways underlying radial artery flow-mediated dilation are preserved in healthy aging.
Article in Journal of aging research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 4 citations in OpenAlex.
- L-Arginine supplementation does not enhance blood flow and muscle performance in healthy and physically active older women.European journal of nutrition · 2016Trial
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Background. Blocking nitric oxide (NO) and vasodilator prostanoids (PN) does not consistently reduce flow-mediated dilation (FMD) in young adults. The impact of aging on the contribution of NO and PG to FMD is unknown. Methods. FMD was measured in older adults (n = 10, 65 ± 3 y) after arterial infusion of saline, N(G)-monomethyl-L-arginine (L-NMMA), and ketorolac + L-NMMA. Data were compared to published data in young adults. Results. L-NMMA reduced FMD in older adults (8.9 ± 3.6 to 5.9 ± 3.7%) although this was not statistically significant (P = 0.08) and did not differ (P = 0.74) from the reduction observed in young adults (10.0 ± 3.8 to 7.6 ± 4.7%; P = 0.03). Blocking PN did not affect FMD in young or older adults. In older adults, L-NMMA reduced (n = 6; range = 36-123% decrease), augmented (n = 3; 10-122% increase), or did not change FMD (n = 1; 0.4% increase). After PN blockade, FMD responses were reduced (n = 2), augmented (n = 6), or unaffected (n = 1). Conclusions. NO or PN blockade did not consistently reduce FMD in healthy older adults, suggesting the existence of redundant vasodilator phenotypes as observed previously in young adults.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.