ReviewEmerging themes in epidemiology2014
Risk factors for non-atopic asthma/wheeze in children and adolescents: a systematic review.
Review in Emerging themes in epidemiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 3 syntheses or guidelines pooled it, 80 citations in OpenAlex.
- Perinatal maternal depression and the risk of childhood asthma in offspring: A meta-analysis.PloS one · 2024Pooled it
- Risk Factors in Preschool Children for Predicting Asthma During the Preschool Age and the Early School Age: a Systematic Review and Meta-Analysis.Current allergy and asthma reports · 2017Pooled it
- Contributions of a Child's Built, Natural, and Social Environments to Their General Cognitive Ability: A Systematic Scoping Review.PloS one · 2016Pooled it
- Preschool Wheeze and the GINA 2025 Paradigm: Challenges and Adaptations for LMICs.Indian pediatrics · 2026Review
- Article
- Secretory IgA modifies the association between early-life gut microbiota trajectories and childhood nonatopic wheeze.ERJ open research · 2025Article
- Understanding and controlling asthma in Latin America: A review of recent research informed by the SCAALA programme.Clinical and translational allergy · 2023Review
- Early-life weight gain is associated with non-atopic asthma in childhood.The World Allergy Organization journal · 2022Article
- Meconium-stained amniotic fluid during labor may be a protective factor for the offspring's childhood wheezing up to 3 years of age: the Japan Environment and Children's Study.European journal of pediatrics · 2022Article
- Association of infant antibiotic exposure and risk of childhood asthma: A meta-analysis.The World Allergy Organization journal · 2021Article
- Article
- Measuring urbanicity as a risk factor for childhood wheeze in a transitional area of coastal ecuador: a cross-sectional analysis.BMJ open respiratory research · 2020Article
- Risk factors for atopic and nonatopic asthma in Puerto Rican children.Pediatric pulmonology · 2020Article
- Factors Associated with the Development of Childhood Asthma in Japan: A Nationwide Longitudinal Study.Maternal and child health journal · 2020Article
- Understanding the dynamics of asthma symptoms between childhood and adolescence using latent transition analysis.International journal of public health · 2020Article
- Domestic Risk Factors for Atopic and non-Atopic Asthma in First Nations Children Living in Saskatchewan, Canada.Children (Basel, Switzerland) · 2020Article
- Considerations for the Child with Nonatopic Asthma.Pediatric allergy, immunology, and pulmonology · 2020Review
- Prevalence and risk factors for asthma, rhinitis, eczema, and atopy among preschool children in an Andean city.PloS one · 2020Article
- A risk factor for early wheezing in infants: rapid weight gain.BMC pediatrics · 2019Article
- Cumulative Impact of Environmental Pollution and Population Vulnerability on Pediatric Asthma Hospitalizations: A Multilevel Analysis of CalEnviroScreen.International journal of environmental research and public health · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundThe study of non-atopic asthma/wheeze in children separately from atopic asthma is relatively recent. Studies have focused on single risk factors and had inconsistent findings.
objectiveTo review evidence on factors associated with non-atopic asthma/wheeze in children and adolescents.
methodsA review of studies of risk factors for non-atopic asthma/wheeze which had a non-asthmatic comparison group, and assessed atopy by skin-prick test or allergen-specific IgE.
resultsStudies of non-atopic asthma/wheeze used a wide diversity of definitions of asthma/wheeze, comparison groups and methods to assess atopy. Among 30 risk factors evaluated in the 43 studies only 3 (family history of asthma/rhinitis/eczema, dampness/mold in the household, and lower respiratory tract infections in childhood) showed consistent associations with non-atopic asthma/wheeze. No or limited period of breastfeeding was less consistently associated with non-atopic asthma/wheeze. The few studies examining the effects of overweight/obesity and psychological/social factors showed consistent associations. We used a novel graphical presentation of different risk factors for non-atopic asthma/wheeze, allowing a more complete perception of the complex pattern of effects.
conclusionsMore research using standardized methodology is needed on the causes of non-atopic asthma.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.