ArticleEvidence-based complementary and alternative medicine : eCAM2014
Evaluation of the in vitro antiplasmodial, antileishmanial, and antitrypanosomal activity of medicinal plants used in saudi and yemeni traditional medicine.
Article in Evidence-based complementary and alternative medicine : eCAM, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Article
- Exploring novel thiazolo[5,4-f]quinoline-based scaffolds as promising antimicrobial agents through synthesis and molecular insights.Scientific reports · 2025Article
- Molecular docking and simulation analysis of selected herbal compounds against GP63, FPPS, and NMT, three importantResearch in pharmaceutical sciences · 2025Article
- Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024Review
- Drug-likeness analysis, in silico ADMET profiling of compounds inIn silico pharmacology · 2024Article
- Evaluation of the Anti-Malarial Activity of the Crude Root Extract and Solvent Fraction ofJournal of experimental pharmacology · 2023Article
- Machine learning enhances prediction of plants as potential sources of antimalarials.Frontiers in plant science · 2023Article
- Ethnobotanical study of endemic and non-endemic medicinal plants used by indigenous people in environs of Gullele botanical garden Addis Ababa, central Ethiopia: A major focus on Asteraceae family.Frontiers in pharmacology · 2022Article
- Botanical candidates from Saudi Arabian flora as potential therapeutics forSaudi journal of biological sciences · 2021Review
- In vitro Antileishmanial Activity of Some Ethiopian Medicinal Plants.Journal of experimental pharmacology · 2021Article
- Potential of the natural products against leishmaniasis in Old World - a review of in-vitro studies.Pathogens and global health · 2020Review
- Analgesic, Anti-Inflammatory, Cytotoxic Activity Screening and UPLC-PDA-ESI-MS Metabolites Determination of Bioactive Fractions ofMolecules (Basel, Switzerland) · 2020Article
- Antimalarial Activity ofJournal of experimental pharmacology · 2020Article
- Chemo Suppressive and Curative Potential ofJournal of experimental pharmacology · 2020Article
- Protective Role ofEvidence-based complementary and alternative medicine : eCAM · 2020Article
- The Genus Solanum: An Ethnopharmacological, Phytochemical and Biological Properties Review.Natural products and bioprospecting · 2019Review
- Traditional use of ethnomedicinal native plants in the Kingdom of Saudi Arabia.Journal of ethnobiology and ethnomedicine · 2019Review
- Efficacy of FourMedicines (Basel, Switzerland) · 2018Article
- Interspecies Anticancer and Antimicrobial Activities of GenusEvidence-based complementary and alternative medicine : eCAM · 2018Article
- A Survey of Chemical Compositions and Biological Activities of Yemeni Aromatic Medicinal Plants.Medicines (Basel, Switzerland) · 2015Review
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5 authors.
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Abstract
The antiplasmodial, antileishmanial, and antitrypanosomal activity of twenty-five medicinal plants distributed in Saudi Arabia and Yemen was evaluated. The plants were extracted with methanol and screened in vitro against erythrocytic schizonts of Plasmodium falciparum, intracellular amastigotes of Leishmania infantum and Trypanosoma cruzi, and free trypomastigotes of T. brucei. To assess selectivity, cytotoxicity was determined on MRC-5 cells. Criteria for activity were an IC50 < 10 μ g/mL and high selectivity (SI). Seven plants showed interesting antiprotozoal activity in one or more models. Extracts of Caralluma penicillata and Acalypha ciliata showed fairly good activity against P. falciparum with IC50 of 6.7 and 10.8 μ g/mL and adequate selectivity (SI > 9.6 and >5.9). Interesting activity against L. infantum was obtained with Verbascum bottae (IC50 of 3.2 μ g/mL, SI 10.2) and Solanum glabratum (IC50 8.1 μ g/mL, SI 3.4). The extracts of C. penicillata, Leucas virgata, Loranthus regularis, and V. bottae exhibited moderate activity against T. brucei (IC50 8.5, 8.1, 8.3, and 2.3 μ g/mL; SI > 7.6, 7.7, 4.3, and >14.1). These results partly support the traditional use of some of the selected medicinal plants and warrant further investigations into the putative active constituents.
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