Evidence map›Paper›PMID 24963327›Full record

ArticleEvidence-based complementary and alternative medicine : eCAM2014

Cytotoxicity of Aporphine, Protoberberine, and Protopine Alkaloids from Dicranostigma leptopodum (Maxim.) Fedde.

Ruiqi Sun, Haiyan Jiang, Wenjuan Zhang, Kai Yang, Chengfang Wang, Li Fan, Qing He, Jiangbin Feng, Shushan Du, Zhiwei Deng and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Evidence-based complementary and alternative medicine : eCAM, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review:Open life sciences · 2024
    Review
  2. Article
  3. Alkaloids ofBiomolecules · 2022
    Article
  4. Article
  5. Article
  6. Anti-Infective and Anti-Cancer Properties of theMolecules (Basel, Switzerland) · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Ruiqi SunAnalytic and Testing Center, Beijing Normal University, No. 19 Xinjiekouwai Street, Haidian District, Beijing 100875, China.ORCID 0000-0002-5433-2380
Haiyan JiangCollege of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, Liaoning 116600, China.
Wenjuan ZhangState Key Laboratory of Earth Surface Processes and Resource Ecology, Beijing Normal University, Beijing 100875, China.
Kai YangState Key Laboratory of Earth Surface Processes and Resource Ecology, Beijing Normal University, Beijing 100875, China.
Chengfang WangKey Laboratory of Radiological Protection and Nuclear Emergency, Chinese Center for Disease Control and Prevention, Haidian District, Beijing 100875, China.
Li FanKey Laboratory of Radiological Protection and Nuclear Emergency, Chinese Center for Disease Control and Prevention, Haidian District, Beijing 100875, China.
Qing HeAnalytic and Testing Center, Beijing Normal University, No. 19 Xinjiekouwai Street, Haidian District, Beijing 100875, China.ORCID 0000-0003-2873-1297
Jiangbin FengKey Laboratory of Radiological Protection and Nuclear Emergency, Chinese Center for Disease Control and Prevention, Haidian District, Beijing 100875, China.
Shushan DuState Key Laboratory of Earth Surface Processes and Resource Ecology, Beijing Normal University, Beijing 100875, China.
Zhiwei DengAnalytic and Testing Center, Beijing Normal University, No. 19 Xinjiekouwai Street, Haidian District, Beijing 100875, China.
Zhufeng GengAnalytic and Testing Center, Beijing Normal University, No. 19 Xinjiekouwai Street, Haidian District, Beijing 100875, China.
Beijing Normal University · CNTaiwan Centers for Disease Control · TWLiaoning University of Traditional Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nine alkaloids with three different structural skeletons were isolated from Dicranostigma leptopodum (Maxim.) Fedde (Papaveraceae) by repeated silica gel column chromatography. Their chemical structures were identified on the basic of physicochemical and spectroscopic data. Among them, 10-O-methylhernovine (1), nantenine (2), corytuberine (3), lagesianine A (4), and dihydrocryptopine (9) were first isolated from this plant. With a series of cytotoxic tests, compounds 2, 3, and 7 displayed cytotoxicity against SMMC-7721 with IC50 values of 70.08 ± 4.63, 73.22 ± 2.35, and 27.77 ± 2.29 μ M, respectively.

Identifiers

PMID24963327
PMCPMC4055583
OpenAlexW2166672280

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.