Evidence map›Paper›PMID 24963217›Full record

ArticleMediators of inflammation2014

Expression of IL-18, IL-18 binding protein, and IL-18 receptor by normal and cancerous human ovarian tissues: possible implication of IL-18 in the pathogenesis of ovarian carcinoma.

Liat Medina, Alex Rabinovich, Benjamin Piura, Victor Dyomin, Ruthy Shaco Levy, Mahmoud Huleihel

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mediators of inflammation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Liat MedinaThe Shraga Segal Department of Microbiology, Immunology and Genetics, Be'er Sheva, Israel ; Faculty of Health Sciences, Ben-Gurion University of the Negev, 84105 Be'er Sheva, Israel.
Alex RabinovichFaculty of Health Sciences, Ben-Gurion University of the Negev, 84105 Be'er Sheva, Israel ; Unit of Gynecologic Oncology, Division of Obstetrics and Gynecology, Soroka University Medical Center, 84105 Be'er Sheva, Israel.
Benjamin PiuraFaculty of Health Sciences, Ben-Gurion University of the Negev, 84105 Be'er Sheva, Israel ; Unit of Gynecologic Oncology, Division of Obstetrics and Gynecology, Soroka University Medical Center, 84105 Be'er Sheva, Israel.
Victor DyominUnit of Gynecologic Oncology, Division of Obstetrics and Gynecology, Soroka University Medical Center, 84105 Be'er Sheva, Israel ; Institute of Pathology, Soroka University Medical Center, 84105 Be'er Sheva, Israel.
Ruthy Shaco LevyUnit of Gynecologic Oncology, Division of Obstetrics and Gynecology, Soroka University Medical Center, 84105 Be'er Sheva, Israel ; Institute of Pathology, Soroka University Medical Center, 84105 Be'er Sheva, Israel.
Mahmoud HuleihelThe Shraga Segal Department of Microbiology, Immunology and Genetics, Be'er Sheva, Israel ; Faculty of Health Sciences, Ben-Gurion University of the Negev, 84105 Be'er Sheva, Israel.
Ben-Gurion University of the Negev · ILSoroka Medical Center · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Proinflammatory cytokine IL-18 has been shown to be elevated in the sera of ovarian carcinoma patients. The aim of the study was to examine the levels and cellular origin of IL-18, IL-18 binding protein, and IL-18 receptor in normal and cancerous ovarian tissues. Ovarian tissue samples were examined by immunohistochemical staining for IL-18, IL-18BP, and IL-18R and mRNA of these cytokines was analyzed with semiquantitative PT-PCR. IL-18 levels were significantly higher in cancerous ovarian tissues (P = 0.0007), IL-18BP levels were significantly higher in normal ovarian tissues (P = 0.04), and the ratio of IL-18/IL-18BP was significantly higher in cancerous ovarian tissues (P = 0.036). Cancerous ovarian tissues expressed significantly higher IL-18 mRNA levels (P = 0.025), while there was no difference in the expression of IL-18BP mRNA and IL-18R mRNA between cancerous and normal ovarian tissues. IL-18 and IL-18BP were expressed dominantly in the epithelial cells of both cancerous and normal ovarian tissues, while IL-18R was expressed dominantly in the epithelial cells of cancerous ovarian tissues but expressed similarly in the epithelial and stromal cells of normal cancerous tissues. This study indicates a possible role of IL-18, IL-18BP, and IL-18R in the pathogenesis of epithelial ovarian carcinoma.

Indexed as

Gene Expression Regulation, NeoplasticCytokinesDisease ProgressionEpithelial CellsFemaleGene Expression ProfilingHumansImmunohistochemistryIntercellular Signaling Peptides and ProteinsInterleukin-18Interleukin-18 Receptor alpha SubunitOvarian NeoplasmsOvaryRNA, MessengerCytokinesIL18R1 protein, humanIntercellular Signaling Peptides and ProteinsInterleukin-18interleukin-18 binding proteinInterleukin-18 Receptor alpha SubunitRNA, Messenger

Identifiers

PMID24963217
PMCPMC4052106
OpenAlexW2087989521

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.