ArticleThe Plant cell2014
The Cyclin-Dependent Kinase Inhibitor KRP6 Induces Mitosis and Impairs Cytokinesis in Giant Cells Induced by Plant-Parasitic Nematodes in Arabidopsis.
Article in The Plant cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 39 citations in OpenAlex.
- Expanding the triangle of U: comparative analysis of the Hirschfeldia incana genome provides insights into chromosomal evolution, phylogenomics and high photosynthesis-related traits.Annals of botany · 2026Article
- A spatiotemporal atlas of giant-cell formation during Meloidogyne incognita infection in tomato roots.Molecular horticulture · 2026Article
- KRP3 Stability Controls Rice Plant Architecture and Productivity via MPK3-Mediated Phosphorylation.Plant biotechnology journal · 2026Article
- Article
- Local and systemic transcriptome and spliceome reprogramming induced by the root-knot nematodeHorticulture research · 2024Article
- Review
- Galls induced by a root-knot nematode in Petroselinum crispum (Mill.): impacts on host development, histology, and cell wall dynamics.Protoplasma · 2023Article
- A G-type lectin receptor kinase negatively regulates Arabidopsis immunity against root-knot nematodes.Plant physiology · 2023Article
- Characterization of the soybean KRP gene family reveals a key role for GmKRP2a in root development.Frontiers in plant science · 2023Article
- The DNA methylation landscape of the root-knot nematode-induced pseudo-organ, the gall, in Arabidopsis, is dynamic, contrasting over time, and critically important for successful parasitism.The New phytologist · 2022Article
- The Minichromosome Maintenance Complex Component 2 (MjMCM2) of Meloidogyne javanica is a potential effector regulating the cell cycle in nematode-induced galls.Scientific reports · 2022Article
- Morphological characterization reveals new insights into giant cell development of Meloidogyne graminicola on rice.Planta · 2022Article
- Plant casein kinases phosphorylate and destabilize a cyclin-dependent kinase inhibitor to promote cell division.Plant physiology · 2021Article
- Identification of genes involved inPlant biotechnology (Tokyo, Japan) · 2021Article
- Article
- CCS52 and DEL1 function in root-knot nematode giant cell development in Xinjiang wild myrobalan plum (Prunus sogdiana Vassilcz).Protoplasma · 2020Article
- Size matters: three methods for estimating nuclear size in mycorrhizal roots of Medicago truncatula by image analysis.BMC plant biology · 2019Article
- Maternal doubled haploid production in interploidy hybridization between Brassica napus and Brassica allooctaploids.Planta · 2018Article
- Genome-wide association study discovered genetic variation and candidate genes of fibre quality traits in Gossypium hirsutum L.Plant biotechnology journal · 2017Article
- Why do plants need so many cyclin-dependent kinase inhibitors?Plant signaling & behavior · 2017Article
Corrections and comments
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Authors and funding
19 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In Arabidopsis thaliana, seven cyclin-dependent kinase (CDK) inhibitors have been identified, designated interactors of CDKs or Kip-related proteins (KRPs). Here, the function of KRP6 was investigated during cell cycle progression in roots infected by plant-parasitic root-knot nematodes. Contrary to expectations, analysis of Meloidogyne incognita-induced galls of KRP6-overexpressing lines revealed a role for this particular KRP as an activator of the mitotic cell cycle. In accordance, KRP6-overexpressing suspension cultures displayed accelerated entry into mitosis, but delayed mitotic progression. Likewise, phenotypic analysis of cultured cells and nematode-induced giant cells revealed a failure in mitotic exit, with the appearance of multinucleated cells as a consequence. Strong KRP6 expression upon nematode infection and the phenotypic resemblance between KRP6 overexpression cell cultures and root-knot morphology point toward the involvement of KRP6 in the multinucleate and acytokinetic state of giant cells. Along these lines, the parasite might have evolved to manipulate plant KRP6 transcription to the benefit of gall establishment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.