Evidence map›Paper›PMID 24963038›Full record

ArticleCirculation2014

Apolipoprotein A-I mimetic peptide 4F rescues pulmonary hypertension by inducing microRNA-193-3p.

Salil Sharma, Soban Umar, Francois Potus, Andrea Iorga, Gabriel Wong, David Meriwether, Sandra Breuils-Bonnet, Denise Mai, Kaveh Navab, David Ross and 6 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
9.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 91 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

Salil SharmaFrom the Department of Anesthesiology, Division of Molecular Medicine (S.S., S.U., A.I., G.W., D. Mai, K.N., M.E.), Department of Medicine, Division of Cardiology (D. Meriwether, K.N., M.N., A.M.F., S.T.R.), Division of Pulmonary Critical Care Medicine (D.R.), Department of Molecular and Medical Pharmacology (S.T.R.), and Cardiovascular Research Laboratories (M.E.), David Geffen School of Medicine at University of California-Los Angeles; and Pulmonary Hypertension Research Group, Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, Québec, Canada (F.P., S.B.-B., S.P., S.B.).
Soban UmarFrom the Department of Anesthesiology, Division of Molecular Medicine (S.S., S.U., A.I., G.W., D. Mai, K.N., M.E.), Department of Medicine, Division of Cardiology (D. Meriwether, K.N., M.N., A.M.F., S.T.R.), Division of Pulmonary Critical Care Medicine (D.R.), Department of Molecular and Medical Pharmacology (S.T.R.), and Cardiovascular Research Laboratories (M.E.), David Geffen School of Medicine at University of California-Los Angeles; and Pulmonary Hypertension Research Group, Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, Québec, Canada (F.P., S.B.-B., S.P., S.B.).
Francois PotusFrom the Department of Anesthesiology, Division of Molecular Medicine (S.S., S.U., A.I., G.W., D. Mai, K.N., M.E.), Department of Medicine, Division of Cardiology (D. Meriwether, K.N., M.N., A.M.F., S.T.R.), Division of Pulmonary Critical Care Medicine (D.R.), Department of Molecular and Medical Pharmacology (S.T.R.), and Cardiovascular Research Laboratories (M.E.), David Geffen School of Medicine at University of California-Los Angeles; and Pulmonary Hypertension Research Group, Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, Québec, Canada (F.P., S.B.-B., S.P., S.B.).
Andrea IorgaFrom the Department of Anesthesiology, Division of Molecular Medicine (S.S., S.U., A.I., G.W., D. Mai, K.N., M.E.), Department of Medicine, Division of Cardiology (D. Meriwether, K.N., M.N., A.M.F., S.T.R.), Division of Pulmonary Critical Care Medicine (D.R.), Department of Molecular and Medical Pharmacology (S.T.R.), and Cardiovascular Research Laboratories (M.E.), David Geffen School of Medicine at University of California-Los Angeles; and Pulmonary Hypertension Research Group, Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, Québec, Canada (F.P., S.B.-B., S.P., S.B.).
Gabriel WongFrom the Department of Anesthesiology, Division of Molecular Medicine (S.S., S.U., A.I., G.W., D. Mai, K.N., M.E.), Department of Medicine, Division of Cardiology (D. Meriwether, K.N., M.N., A.M.F., S.T.R.), Division of Pulmonary Critical Care Medicine (D.R.), Department of Molecular and Medical Pharmacology (S.T.R.), and Cardiovascular Research Laboratories (M.E.), David Geffen School of Medicine at University of California-Los Angeles; and Pulmonary Hypertension Research Group, Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, Québec, Canada (F.P., S.B.-B., S.P., S.B.).
David MeriwetherFrom the Department of Anesthesiology, Division of Molecular Medicine (S.S., S.U., A.I., G.W., D. Mai, K.N., M.E.), Department of Medicine, Division of Cardiology (D. Meriwether, K.N., M.N., A.M.F., S.T.R.), Division of Pulmonary Critical Care Medicine (D.R.), Department of Molecular and Medical Pharmacology (S.T.R.), and Cardiovascular Research Laboratories (M.E.), David Geffen School of Medicine at University of California-Los Angeles; and Pulmonary Hypertension Research Group, Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, Québec, Canada (F.P., S.B.-B., S.P., S.B.).
Sandra Breuils-BonnetFrom the Department of Anesthesiology, Division of Molecular Medicine (S.S., S.U., A.I., G.W., D. Mai, K.N., M.E.), Department of Medicine, Division of Cardiology (D. Meriwether, K.N., M.N., A.M.F., S.T.R.), Division of Pulmonary Critical Care Medicine (D.R.), Department of Molecular and Medical Pharmacology (S.T.R.), and Cardiovascular Research Laboratories (M.E.), David Geffen School of Medicine at University of California-Los Angeles; and Pulmonary Hypertension Research Group, Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, Québec, Canada (F.P., S.B.-B., S.P., S.B.).
Denise MaiFrom the Department of Anesthesiology, Division of Molecular Medicine (S.S., S.U., A.I., G.W., D. Mai, K.N., M.E.), Department of Medicine, Division of Cardiology (D. Meriwether, K.N., M.N., A.M.F., S.T.R.), Division of Pulmonary Critical Care Medicine (D.R.), Department of Molecular and Medical Pharmacology (S.T.R.), and Cardiovascular Research Laboratories (M.E.), David Geffen School of Medicine at University of California-Los Angeles; and Pulmonary Hypertension Research Group, Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, Québec, Canada (F.P., S.B.-B., S.P., S.B.).
Kaveh NavabFrom the Department of Anesthesiology, Division of Molecular Medicine (S.S., S.U., A.I., G.W., D. Mai, K.N., M.E.), Department of Medicine, Division of Cardiology (D. Meriwether, K.N., M.N., A.M.F., S.T.R.), Division of Pulmonary Critical Care Medicine (D.R.), Department of Molecular and Medical Pharmacology (S.T.R.), and Cardiovascular Research Laboratories (M.E.), David Geffen School of Medicine at University of California-Los Angeles; and Pulmonary Hypertension Research Group, Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, Québec, Canada (F.P., S.B.-B., S.P., S.B.).
David RossFrom the Department of Anesthesiology, Division of Molecular Medicine (S.S., S.U., A.I., G.W., D. Mai, K.N., M.E.), Department of Medicine, Division of Cardiology (D. Meriwether, K.N., M.N., A.M.F., S.T.R.), Division of Pulmonary Critical Care Medicine (D.R.), Department of Molecular and Medical Pharmacology (S.T.R.), and Cardiovascular Research Laboratories (M.E.), David Geffen School of Medicine at University of California-Los Angeles; and Pulmonary Hypertension Research Group, Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, Québec, Canada (F.P., S.B.-B., S.P., S.B.).
Mohamad NavabFrom the Department of Anesthesiology, Division of Molecular Medicine (S.S., S.U., A.I., G.W., D. Mai, K.N., M.E.), Department of Medicine, Division of Cardiology (D. Meriwether, K.N., M.N., A.M.F., S.T.R.), Division of Pulmonary Critical Care Medicine (D.R.), Department of Molecular and Medical Pharmacology (S.T.R.), and Cardiovascular Research Laboratories (M.E.), David Geffen School of Medicine at University of California-Los Angeles; and Pulmonary Hypertension Research Group, Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, Québec, Canada (F.P., S.B.-B., S.P., S.B.).
Steeve ProvencherFrom the Department of Anesthesiology, Division of Molecular Medicine (S.S., S.U., A.I., G.W., D. Mai, K.N., M.E.), Department of Medicine, Division of Cardiology (D. Meriwether, K.N., M.N., A.M.F., S.T.R.), Division of Pulmonary Critical Care Medicine (D.R.), Department of Molecular and Medical Pharmacology (S.T.R.), and Cardiovascular Research Laboratories (M.E.), David Geffen School of Medicine at University of California-Los Angeles; and Pulmonary Hypertension Research Group, Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, Québec, Canada (F.P., S.B.-B., S.P., S.B.).
Alan M FogelmanFrom the Department of Anesthesiology, Division of Molecular Medicine (S.S., S.U., A.I., G.W., D. Mai, K.N., M.E.), Department of Medicine, Division of Cardiology (D. Meriwether, K.N., M.N., A.M.F., S.T.R.), Division of Pulmonary Critical Care Medicine (D.R.), Department of Molecular and Medical Pharmacology (S.T.R.), and Cardiovascular Research Laboratories (M.E.), David Geffen School of Medicine at University of California-Los Angeles; and Pulmonary Hypertension Research Group, Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, Québec, Canada (F.P., S.B.-B., S.P., S.B.).
Sébastien BonnetFrom the Department of Anesthesiology, Division of Molecular Medicine (S.S., S.U., A.I., G.W., D. Mai, K.N., M.E.), Department of Medicine, Division of Cardiology (D. Meriwether, K.N., M.N., A.M.F., S.T.R.), Division of Pulmonary Critical Care Medicine (D.R.), Department of Molecular and Medical Pharmacology (S.T.R.), and Cardiovascular Research Laboratories (M.E.), David Geffen School of Medicine at University of California-Los Angeles; and Pulmonary Hypertension Research Group, Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, Québec, Canada (F.P., S.B.-B., S.P., S.B.).
Srinivasa T ReddyFrom the Department of Anesthesiology, Division of Molecular Medicine (S.S., S.U., A.I., G.W., D. Mai, K.N., M.E.), Department of Medicine, Division of Cardiology (D. Meriwether, K.N., M.N., A.M.F., S.T.R.), Division of Pulmonary Critical Care Medicine (D.R.), Department of Molecular and Medical Pharmacology (S.T.R.), and Cardiovascular Research Laboratories (M.E.), David Geffen School of Medicine at University of California-Los Angeles; and Pulmonary Hypertension Research Group, Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, Québec, Canada (F.P., S.B.-B., S.P., S.B.).
Mansoureh EghbaliFrom the Department of Anesthesiology, Division of Molecular Medicine (S.S., S.U., A.I., G.W., D. Mai, K.N., M.E.), Department of Medicine, Division of Cardiology (D. Meriwether, K.N., M.N., A.M.F., S.T.R.), Division of Pulmonary Critical Care Medicine (D.R.), Department of Molecular and Medical Pharmacology (S.T.R.), and Cardiovascular Research Laboratories (M.E.), David Geffen School of Medicine at University of California-Los Angeles; and Pulmonary Hypertension Research Group, Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, Québec, Canada (F.P., S.B.-B., S.P., S.B.). meghbali@ucla.edu.
Norwegian Womens Public Health Association · NO

Funding

UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
ULTRASTRUCTURE OF THE INTIMA IN EARLY LESION FORMATIONP01HL030568 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FOGELMAN, ALAN M · 1985 to 2019
$55.2M
The role of PON2 and PON3 proteins in AtherosclerosisR01HL071776 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI REDDY, SRINIVASA T. · 2003 to 2017
$4.8M
Neuroendocrinology, Sex Differences, and ReproductionT32HD007228 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARNOLD, ARTHUR P · 1985 to 2015
$3.9M
Cardiac KCNE2 (MIRP1) Regulation by Estrogen and Cardiac StressR01HL089876 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EGHBALI, MANSOUREH · 2008 to 2012
$2.2M
Training in Molecular, Cellular &Integrative PhysiologyT32GM065823 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TIDBALL, JAMES G · 2003 to 2017
$2.1M
CIHRNCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1TR000124NHLBI NIH HHS HL-30568NHLBI NIH HHS P01 HL030568NHLBI NIH HHS R01 HL071776NHLBI NIH HHS R01 HL089876NHLBI NIH HHS R01HL-089876NICHD NIH HHS 5T32HD007228-32NICHD NIH HHS T32 HD007228NIGMS NIH HHS T32 GM065823
6 · The paper itself

Abstract

backgroundPulmonary arterial hypertension is a chronic lung disease associated with severe pulmonary vascular changes. A pathogenic role of oxidized lipids such as hydroxyeicosatetraenoic and hydroxyoctadecadienoic acids is well established in vascular disease. Apolipoprotein A-I mimetic peptides, including 4F, have been reported to reduce levels of these oxidized lipids and improve vascular disease. However, the role of oxidized lipids in the progression of pulmonary arterial hypertension and the therapeutic action of 4F in pulmonary arterial hypertension are not well established. METHODS AND

resultsWe studied 2 different rodent models of pulmonary hypertension (PH): a monocrotaline rat model and a hypoxia mouse model. Plasma levels of hydroxyeicosatetraenoic and hydroxyoctadecadienoic acids were significantly elevated in PH. 4F treatment reduced these levels and rescued preexisting PH in both models. MicroRNA analysis revealed that microRNA-193-3p (miR193) was significantly downregulated in the lung tissue and serum from both patients with pulmonary arterial hypertension and rodents with PH. In vivo miR193 overexpression in the lungs rescued preexisting PH and resulted in downregulation of lipoxygenases and insulin-like growth factor-1 receptor. 4F restored PH-induced miR193 expression via transcription factor retinoid X receptor α.

conclusionsThese studies establish the importance of microRNAs as downstream effectors of an apolipoprotein A-I mimetic peptide in the rescue of PH and suggest that treatment with apolipoprotein A-I mimetic peptides or miR193 may have therapeutic value.

Indexed as

AnimalsCell ProliferationCells, CulturedHumansHydroxyeicosatetraenoic AcidsHypertension, PulmonaryMaleMiceMice, Inbred C57BLMicroRNAsMuscle, Smooth, VascularPeptidesRatsRats, Sprague-DawleyReceptor, IGF Type 1Retinoid X Receptor alpha15-hydroxy-5,8,11,13-eicosatetraenoic acidapolipoprotein A-I mimetic peptide 4FHydroxyeicosatetraenoic AcidsMicroRNAsMIRN193 microRNA, mouseMirn193 microRNA, ratPeptidesReceptor, IGF Type 1Retinoid X Receptor alphaapolipoprotein A-I mimetic peptide 4FlipoproteinsmicroRNAsmiR-193, humanpulmonary arterial hypertension

Identifiers

PMID24963038
PMCPMC4194270
OpenAlexW2147789234

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.