Evidence map›Paper›PMID 24962475›Full record

ArticleMagnetic resonance in medicine2015

Respiratory self-gating for free-breathing magnetization transfer MRI of the abdomen.

Weiguo Li, Zhuoli Zhang, Kangan Li, Ning Jin, Yue Zhang, Tianjing Zhang, Frank H Miller, Andrew C Larson

Open access · bronzeAbstract read
In one paragraph

Article in Magnetic resonance in medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Weiguo LiDepartment of Radiology, Northwestern University, Chicago, Illinois, USA.
Zhuoli ZhangDepartment of Radiology, Northwestern University, Chicago, Illinois, USA.
Kangan LiDepartment of Radiology, Northwestern University, Chicago, Illinois, USA.
Ning JinSiemens Healthcare, Columbus, Ohio, USA.
Yue ZhangDepartment of Radiology, Northwestern University, Chicago, Illinois, USA.
Tianjing ZhangDepartment of Radiology, Northwestern University, Chicago, Illinois, USA.
Frank H MillerDepartment of Radiology, Northwestern University, Chicago, Illinois, USA.
Andrew C LarsonDepartment of Radiology, Northwestern University, Chicago, Illinois, USA.
Northwestern University · USSiemens Healthcare (Germany) · DE

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Daniela E Matei · 1993 to 2026
$153.9M
MRI-Monitored Delivery of Sorafenib-Eluting Microspheres to Liver TumorsR01CA181658 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LARSON, ANDREW CHRISTIAN · 2015 to 2019
$2.1M
MRI-Guided Irreversible Electroporation Ablation for Liver TumorsR01CA196967 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ZHANG, ZHUOLI · 2015 to 2018
$1.4M
Functional MRI Monitoring of Hepatic ChemoembolizationR01CA126809 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LARSON, ANDREW CHRISTIAN · 2008 to 2011
$1.2M
Transcatheter Intra-arterial Perfusion MRI Monitoring of Liver Tumor EmbolizationR01CA134719 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LARSON, ANDREW CHRISTIAN · 2008 to 2010
$908k
NCI NIH HHS CA134719NCI NIH HHS P30 CA060553NCI NIH HHS R01 CA126809NCI NIH HHS R01 CA134719NCI NIH HHS R01 CA181658NCI NIH HHS R01 CA196967NCRR NIH HHS UL1RR0254741
6 · The paper itself

Abstract

purposeMagnetization transfer (MT) MRI can be effective for the diagnosis of a broad range of fibrotic diseases, including liver fibrosis. However, respiratory motion, a major source of artifacts in thoracic and abdominal MR imaging, can obscure important anatomic structures, making diagnosis difficult. In this study, we explored the potential to combine free-breathing (FB) respiratory self-gating (RSG) methods with MT saturation for FB MT ratio (MTR) measurements of abdominal organs.

methodsA respiratory self-gated multiple-gradient recalled echo sequence with MT presaturation (RSG-MT GRE) was developed and applied in a series of seven normal volunteers. We compared the MTR values of liver, pancreas, kidney, spleen, and posterior paraspinal muscle measured using our RSG-MT GRE sequence and a conventional MT GRE sequence.

resultsRSG consistently reduced motion artifacts within MT-weighted images acquired during FB, improved the accuracy of FB MTR measurements, and produced comparable MTRs to breath-holding MTR measurements.

conclusionRSG approaches may offer to improve the utility of MT-weighted imaging methods for the assessment of fibrotic diseases and tumor desmoplasia in abdominal organs.

Indexed as

Respiratory-Gated Imaging TechniquesArtifactsFemaleHealthy VolunteersHumansImage EnhancementImage Processing, Computer-AssistedKidneyLiverMagnetic Resonance ImagingMaleMuscle, SkeletalPancreasSpleenYoung Adultabdomenmagnetization transferrespiratory motionrespiratory self-gating

Identifiers

PMID24962475
PMCPMC4276560
OpenAlexW2156551417

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.