ArticleDrug and alcohol dependence2014
Genome-wide survival analysis of age at onset of alcohol dependence in extended high-risk COGA families.
Article in Drug and alcohol dependence, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Shared genetic etiology between alcohol dependence and major depressive disorder.Psychiatric genetics · 2018Pooled it
- Pooled it
- Polygenic Scores for Major Depressive Disorder and Risk of Alcohol Dependence.JAMA psychiatry · 2017Pooled it
- Identification of novel genetic loci and candidate genes for progressive ethanol consumption in diversity outbred mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- The collaborative study on the genetics of alcoholism: Sample and clinical data.Genes, brain, and behavior · 2023Review
- The collaborative study on the genetics of alcoholism: Genetics.Genes, brain, and behavior · 2023Review
- The shared genetic architecture of suicidal behaviour and psychiatric disorders: A genomic structural equation modelling study.Frontiers in genetics · 2023Article
- Scalable and Robust Regression Methods for Phenome-Wide Association Analysis on Large-Scale Biobank Data.Frontiers in genetics · 2021Review
- Genetic architecture of cardiometabolic risks in people living with HIV.BMC medicine · 2020Article
- A Fast and Accurate Method for Genome-Wide Time-to-Event Data Analysis and Its Application to UK Biobank.American journal of human genetics · 2020Article
- Recent advances in genetic studies of alcohol use disorders.Current genetic medicine reports · 2020Article
- Genetic determinants of beverage consumption: Implications for nutrition and health.Advances in food and nutrition research · 2019Review
- A Whole Methylome Study of Ethanol Exposure in Brain and Blood: An Exploration of the Utility of Peripheral Blood as Proxy Tissue for Brain in Alcohol Methylation Studies.Alcoholism, clinical and experimental research · 2018Article
- Polygenic Risk Score Prediction of Alcohol Dependence Symptoms Across Population-Based and Clinically Ascertained Samples.Alcoholism, clinical and experimental research · 2018Article
- Genome-Wide Association Study of Dietary Pattern Scores.Nutrients · 2017Article
- Using an Event-History with Risk-Free Model to Study the Genetics of Alcoholism.Scientific reports · 2017Article
- Genome-wide polygenic scores for age at onset of alcohol dependence and association with alcohol-related measures.Translational psychiatry · 2016Article
- DISC1 as a Possible Genetic Contribution to Opioid Dependence in a Polish Sample.Journal of studies on alcohol and drugs · 2016Article
- Genetic and Environmental Interplay in Adolescent Substance Use Disorders.Current addiction reports · 2015Article
- Article
Corrections and comments
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Authors and funding
24 authors at 9 institutions in 1 country.
Funding
Abstract
backgroundThe age at onset of alcohol dependence (AD) is a critical moderator of genetic associations for alcohol dependence. The present study evaluated whether single nucleotide polymorphisms (SNPs) can influence the age at onset of AD in large high-risk families from the Collaborative Study on the Genetics of Alcoholism (COGA).
methodsGenomewide SNP genotyping was performed in 1788 regular drinkers from 118 large European American families densely affected with alcoholism. We used a genome-wide Cox proportional hazards regression model to test for association between age at onset of AD and SNPs.
resultsThis family-based analysis identified an intergenic SNP, rs2168784 on chromosome 3 that showed strong evidence of association (P=5×10(-9)) with age at onset of AD among regular drinkers. Carriers of the minor allele of rs2168784 had 1.5 times the hazard of AD onset as compared with those homozygous for the major allele. By the age of 20 years, nearly 30% of subjects homozygous for the minor allele were alcohol dependent while only 19% of those homozygous for the major allele were. We also identified intronic SNPs in the ADP-ribosylation factor like 15 (ARL15) gene on chromosome 5 (P=1.11×10(-8)) and the UTP20 small subunit (UTP20) gene on chromosome 12 (P=4.32×10(-8)) that were associated with age at onset of AD.
conclusionsThis extended family based genome-wide cox-proportional hazards analysis identified several loci that might be associated with age at onset of AD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.