ArticleGenetics, selection, evolution : GSE2014
Indirect genetic effects and inbreeding: consequences of BLUP selection for socially affected traits on rate of inbreeding.
Article in Genetics, selection, evolution : GSE, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed.
- Comparison of pooled semen insemination and single colony insemination as sustainable honeybee breeding strategies.Royal Society open science · 2024Article
- Whole-genome re-sequencing provides key genomic insights in farmed Arctic charr (Evolutionary applications · 2023Article
- Statistical model and testing designs to increase response to selection with constrained inbreeding in genomic breeding programs for pigs affected by social genetic effects.Genetics, selection, evolution : GSE · 2021Article
- Genetic Diversity in the Portuguese Mertolenga Cattle Breed Assessed by Pedigree Analysis.Animals : an open access journal from MDPI · 2020Article
- Long-Term Evaluation of Breeding Scheme Alternatives for Endangered Honeybee Subspecies.Insects · 2020Article
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Abstract
backgroundSocial interactions often occur among living organisms, including aquatic animals. There is empirical evidence showing that social interactions may genetically affect phenotypes of individuals and their group mates. In this context, the heritable effect of an individual on the phenotype of another individual is known as an Indirect Genetic Effect (IGE). Selection for socially affected traits may increase response to artificial selection, but also affect rate of inbreeding.
methodsA simulation study was conducted to examine the effect of Best Linear Unbiased Prediction (BLUP) selection for socially affected traits on the rate of inbreeding. A base scenario without IGE and three alternative scenarios with different magnitudes of IGE were simulated. In each generation, 25 sires and 50 dams were mated, producing eight progeny per dam. The population was selected for 20 generations using BLUP. Individuals were randomly assigned to groups of eight members in each generation, with two families per group, each contributing four individuals. "Heritabilities" (for both direct and indirect genetic effects) were equal to 0.1, 0.3 or 0.5, and direct-indirect genetic correlations were -0.8, -0.4, 0, 0.4, or 0.8. The rate of inbreeding was calculated from generation 10 to 20.
resultsFor the base scenario, the rates of inbreeding were 4.09, 2.80 and 1.95% for "heritabilities" of 0.1, 0.3 and 0.5, respectively. Overall, rates of inbreeding for the three scenarios with IGE ranged from 2.21 to 5.76% and were greater than for the base scenarios. The results show that social interaction within groups of two families increases the resemblance between estimated breeding values of relatives, which, in turn, increases the rate of inbreeding.
conclusionBLUP selection for socially affected traits increased the rate of inbreeding. To maintain inbreeding at an acceptable rate, a selection algorithm that restricts the increase in mean kinship, such as optimum contribution selection, is required.
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