Evidence map›Paper›PMID 24961971›Full record

ReviewHandbook of experimental pharmacology2014

TRPs in taste and chemesthesis.

Stephen D Roper

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Handbook of experimental pharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 2 pooled it
25.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 2 syntheses or guidelines pooled it, 139 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Unique and shared patterns of chemosensory dysfunction distinguish chronic COVID-19 and aspirin-exacerbated respiratory disease.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2026
    Article
  5. Review
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  8. Article
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  12. Article
  13. Observational
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  15. Article
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  19. Immune sensing of food allergens promotes aversive behaviour.bioRxiv : the preprint server for biology · 2023
    Article
  20. The evolution of sour taste.Proceedings. Biological sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Stephen D RoperDepartment of Physiology and Biophysics, Miller School of Medicine, University of Miami, 1600 NW 10th Ave., Miami, FL, 33136, USA, sroper@med.miami.edu.
University of Miami · US

Funding

CHEMOSENSORY TRANSDUCTION IN TASTE CELLSR01DC000374 · NIDCD · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ROPER, STEPHEN D. · 1989 to 2012
$4.2M
A new method to measure taste bud functionR01DC007630 · NIDCD · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ROPER, STEPHEN D. · 2006 to 2016
$3.1M
Imaging Molecules and Circuits in Peripheral Taste PathwaysR01DC014420 · NIDCD · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI CHAUDHARI, NIRUPA, ROPER, STEPHEN D. · 2015 to 2019
$1.3M
NIDCD NIH HHS R01 DC000374NIDCD NIH HHS R01 DC007630NIDCD NIH HHS R01 DC014420
6 · The paper itself

Abstract

TRP channels are expressed in taste buds, nerve fibers, and keratinocytes in the oronasal cavity. These channels play integral roles in transducing chemical stimuli, giving rise to sensations of taste, irritation, warmth, coolness, and pungency. Specifically, TRPM5 acts downstream of taste receptors in the taste transduction pathway. TRPM5 channels convert taste-evoked intracellular Ca(2+) release into membrane depolarization to trigger taste transmitter secretion. PKD2L1 is expressed in acid-sensitive (sour) taste bud cells but is unlikely to be the transducer for sour taste. TRPV1 is a receptor for pungent chemical stimuli such as capsaicin and for several irritants (chemesthesis). It is controversial whether TRPV1 is present in the taste buds and plays a direct role in taste. Instead, TRPV1 is expressed in non-gustatory sensory afferent fibers and in keratinocytes of the oronasal cavity. In many sensory fibers and epithelial cells lining the oronasal cavity, TRPA1 is also co-expressed with TRPV1. As with TRPV1, TRPA1 transduces a wide variety of irritants and, in combination with TRPV1, assures that there is a broad response to noxious chemical stimuli. Other TRP channels, including TRPM8, TRPV3, and TRPV4, play less prominent roles in chemesthesis and no known role in taste, per se. The pungency of foods and beverages is likely highly influenced by the temperature at which they are consumed, their acidity, and, for beverages, their carbonation. All these factors modulate the activity of TRP channels in taste buds and in the oronasal mucosa.

Indexed as

AnimalsChemoreceptor CellsHumansTasteTaste BudsTransient Receptor Potential ChannelsTransient Receptor Potential Channels

Identifiers

PMID24961971
PMCPMC4667542
OpenAlexW78209839

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.