ArticleObesity (Silver Spring, Md.)2014
Quantifying energy intake changes during obesity pharmacotherapy.
Article in Obesity (Silver Spring, Md.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Host-diet-gut microbiome interactions influence human energy balance: a randomized clinical trial.Nature communications · 2023Trial
- Glucagon-like peptide-1/glucagon receptor agonism associates with reduced metabolic adaptation and higher fat oxidation: A randomized trial.Obesity (Silver Spring, Md.) · 2023Trial
- Physiology of the weight-loss plateau in response to diet restriction, GLP-1 receptor agonism, and bariatric surgery.Obesity (Silver Spring, Md.) · 2024Article
- Energy homeostasis from Lavoisier to control theory.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Objective versus Self-Reported Energy Intake Changes During Low-Carbohydrate and Low-Fat Diets.Obesity (Silver Spring, Md.) · 2019Article
- Proportional Feedback Control of Energy Intake During Obesity Pharmacotherapy.Obesity (Silver Spring, Md.) · 2017Article
- Translational Modeling to Guide Study Design and Dose Choice in Obesity Exemplified by AZD1979, a Melanin-concentrating Hormone Receptor 1 Antagonist.CPT: pharmacometrics & systems pharmacology · 2017Article
- PF-05231023, a long-acting FGF21 analogue, decreases body weight by reduction of food intake in non-human primates.Journal of pharmacokinetics and pharmacodynamics · 2016Article
- Input estimation for drug discovery using optimal control and Markov chain Monte Carlo approaches.Journal of pharmacokinetics and pharmacodynamics · 2016Article
- Estimating human energy intake using mathematical models.The American journal of clinical nutrition · 2014Article
- Novel mathematical models for investigating topics in obesity.Advances in nutrition (Bethesda, Md.) · 2014Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
objectiveDespite the fact that most obesity drugs primarily work by reducing metabolizable energy intake, elucidation of the time course of energy intake changes during long-term obesity pharmacotherapy has been prevented by the limitations of self-report methods of measuring energy intake.
methodsA validated mathematical model of human metabolism was used to provide the first quantification of metabolizable energy intake changes during long-term obesity pharmacotherapy using body weight data from randomized, placebo-controlled trials that evaluated 14 different drugs or drug combinations.
resultsChanges in metabolizable energy intake during obesity pharmacotherapy were reasonably well-described by an exponential pattern comprising three simple parameters, with early large changes in metabolizable energy intake followed by a slow transition to a smaller persistent drug effect.
conclusionsRepeated body weight measurements along with a mathematical model of human metabolism can be used to quantify changes in metabolizable energy intake during obesity pharmacotherapy. The calculated metabolizable energy intake changes followed an exponential time course, and therefore different drugs can be evaluated and compared using a common mathematical framework.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.