ArticleBrain sciences2014
Propofol exposure in pregnant rats induces neurotoxicity and persistent learning deficit in the offspring.
Article in Brain sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
23 citing papers in PubMed, 56 citations in OpenAlex.
- Intermittent Propofol Exposure Induces Neurodevelopmental Alterations in Human Brain Organoids.Cellular and molecular neurobiology · 2026Article
- High-Dose Propofol Induces Cytotoxicity by Elevating Intracellular CaDrug design, development and therapy · 2026Article
- A retrospective study comparing maternal-infant outcome analysis of live births from patients undergoing painless oocyte retrieval versus conventional oocyte retrieval.BMC pregnancy and childbirth · 2025Article
- Suberoylanilide hydroxamic acid attenuates cognitive impairment in offspring caused by maternal surgery during mid-pregnancy.PloS one · 2024Article
- Determination of the embryotoxic effects of propofol injected into eggs on the cerebellum and spinal cord using histologic methods: an animal study.Turkish journal of medical sciences · 2024Article
- Determination of Embryotoxic Effects of In Ovo Administered Propofol on Peripheral Blood Alpha Naphthyl Acetate Esterase and Acid Phosphatase-Positive Lymphocytes.Turkish journal of anaesthesiology and reanimation · 2023Article
- Analgesia for fetal pain during prenatal surgery: 10 years of progress.Pediatric research · 2021Review
- Prophylactic Melatonin Treatment Ameliorated Propofol-Induced Cognitive Dysfunction in Aged Rats.Neurotoxicity research · 2021Article
- Effects of Maternal Abdominal Surgery on Fetal Brain Development in the Rabbit Model.Fetal diagnosis and therapy · 2021Article
- MicroRNA-665 mediates propofol-induced cell apoptosis in human stem cell-derived neurons.Bioengineered · 2019Article
- [Effect of propofol on myelin basic protein expression and myelination of oligodendrocytes in neonatal SD rats].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2019Article
- Sevoflurane Affects Oxidative Stress and Alters Apoptosis Status in Children and Cultured Neural Stem Cells.Neurotoxicity research · 2018Article
- Propofol exposure during early gestation impairs learning and memory in rat offspring by inhibiting the acetylation of histone.Journal of cellular and molecular medicine · 2018Article
- Pink1 attenuates propofol-induced apoptosis and oxidative stress in developing neurons.Journal of anesthesia · 2018Article
- [Effects of propofol on myelin basic protein expression in oligodendrocytes of SD rats at different developmental stages].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2017Article
- Propofol's Effects on the Fetal Brain for Non-Obstetric Surgery.Brain sciences · 2017Review
- Neonatal Propofol Anesthesia Changes Expression of Synaptic Plasticity Proteins and Increases Stereotypic and Anxyolitic Behavior in Adult Rats.Neurotoxicity research · 2017Article
- Effects of Propofol Treatment in Neural Progenitors Derived from Human-Induced Pluripotent Stem Cells.Neural plasticity · 2017Article
- Recent Insights Into Molecular Mechanisms of Propofol-Induced Developmental Neurotoxicity: Implications for the Protective Strategies.Anesthesia and analgesia · 2016Review
- Propofol exposure during late stages of pregnancy impairs learning and memory in rat offspring via the BDNF-TrkB signalling pathway.Journal of cellular and molecular medicine · 2016Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Propofol is a general anesthetic widely used in surgical procedures, including those in pregnant women. Preclinical studies suggest that propofol may cause neuronal injury to the offspring of primates if it is administered during pregnancy. However, it is unknown whether those neuronal changes would lead to long-term behavioral deficits in the offspring. In this study, propofol (0.4 mg/kg/min, IV, 2 h), saline, or intralipid solution was administered to pregnant rats on gestational day 18. We detected increased levels of cleaved caspase-3 in fetal brain at 6 h after propofol exposure. The neuronal density of the hippocampus of offspring was reduced significantly on postnatal day 10 (P10) and P28. Synaptophysin levels were also significantly reduced on P28. Furthermore, exploratory and learning behaviors of offspring rats (started at P28) were assessed in open-field trial and eight-arm radial maze. The offspring from propofol-treated dams showed significantly less exploratory activity in the open-field test and less spatial learning in the eight-arm radial maze. Thus, this study suggested that propofol exposure during pregnancy in rat increased cleaved caspsase-3 levels in fetal brain, deletion of neurons, reduced synaptophysin levels in the hippocampal region, and persistent learning deficits in the offspring.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.