ArticleBrain sciences2014
A double-edged sword: volatile anesthetic effects on the neonatal brain.
Article in Brain sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Tale of Two Cities: narrative review of oxygen.F1000Research · 2023Pooled it
- The use of ultrasound guidance for perioperative neuraxial and peripheral nerve blocks in children.The Cochrane database of systematic reviews · 2016Pooled it
- Low-Dose Sevoflurane May Reduce Blood Loss and Need for Blood Products After Cardiac Surgery: A Prospective, Randomized Pilot Study.Medicine · 2016Trial
- Different damaging effects of volatile anaesthetics alone or in combination with 1 and 2 Gy gamma-irradiationArhiv za higijenu rada i toksikologiju · 2023Article
- Inhibition of ERK/CREB signaling contributes to postoperative learning and memory dysfunction in neonatal rats.Journal of molecular medicine (Berlin, Germany) · 2023Article
- Glial cell-derived neurotrophic factor decrease may mediate learning, memory and behavior impairments in rats after neonatal surgery.Brain research bulletin · 2022Article
- δ-Opioid Receptor Activation Attenuates Hypoxia/MPPMolecular neurobiology · 2019Article
- General anesthesia combined with epidural anesthesia on the postoperative cognitive functions in pregnant women with dystocia.Experimental and therapeutic medicine · 2018Article
- Inhibition of GSK-3beta Signaling Pathway Rescues Ketamine-Induced Neurotoxicity in Neural Stem Cell-Derived Neurons.Neuromolecular medicine · 2018Article
- Decrease of glial cell-derived neurotrophic factor contributes to anesthesia- and surgery-induced learning and memory dysfunction in neonatal rats.Journal of molecular medicine (Berlin, Germany) · 2017Article
- Dose-dependent effects of sevoflurane exposure during early lifetime on apoptosis in hippocampus and neurocognitive outcomes in Sprague-Dawley rats.International journal of physiology, pathophysiology and pharmacology · 2016Article
- Increased mitochondrial ATP production capacity in brain of healthy mice and a mouse model of isolated complex I deficiency after isoflurane anesthesia.Journal of inherited metabolic disease · 2016Article
- Neurodevelopmental implications of the general anesthesia in neonate and infants.Experimental neurology · 2015Review
- Neonatal exposure to sevoflurane may not cause learning and memory deficits and behavioral abnormality in the childhood of Cynomolgus monkeys.Scientific reports · 2015Article
- Anesthetic effects on autophagy.Medical gas researchReview
- Argon attenuates the emergence of secondary injury after traumatic brain injury within a 2-hour incubation period compared to desflurane: anMedical gas researchArticle
- Neuroprotection provided by isoflurane pre-conditioning and post-conditioning.Medical gas researchReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The use of volatile anesthetics, a group of general anesthetics, is an exceedingly common practice. These anesthetics may have neuroprotective effects. Over the last decade, anesthetic induced neurotoxicity in pediatric populations has gained a certain notoriety based on pre-clinical cell and animal studies demonstrating that general anesthetics may induce neurotoxicity, including neuroapoptosis, neurodegeneration, and long-term neurocognitive and behavioral deficits. With hundreds of millions of people having surgery under general anesthesia worldwide, and roughly six million children annually in the U.S. alone, the importance of clearly defining toxic or protective effects of general anesthetics cannot be overstated. Yet, with our expanding body of knowledge, we have come to learn that perhaps not all volatile anesthetics have the same pharmacological profiles; certain ones may have a more favorable neurotoxic profile and may actually exhibit neuroprotection in specific populations and situations. Thus far, very few clinical studies exist, and have not yet been convincing enough to alter our practice. This review will provide an update on current data regarding volatile anesthetic induced neurotoxicity and neuroprotection in neonatal and infant populations. In addition, this paper will discuss ongoing studies and the trajectory of further research over the coming years.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.