ArticleBrain sciences2014
Anaesthetics-induced neurotoxicity in developing brain: an update on preclinical evidence.
Article in Brain sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 42 citations in OpenAlex.
- Sevoflurane versus propofol and the long-term risk of attention-deficit/hyperactivity disorder in children.General psychiatry · 2026Article
- Efficient analysis of toxicity and mechanisms of isoflurane on postoperative delirium by network toxicology and molecular docking.Neuroprotection (Chichester, England) · 2025Article
- Effect of electroencephalogram-guided anesthesia on postoperative delirium in older adults after surgery: a systematic review and meta-analysis.Frontiers in neurology · 2025Article
- Global Trends and Hotspots in Pediatric Anesthetic Neurotoxicity Research: A Bibliometric Analysis From 2000 to 2023.Cureus · 2024Review
- Oxygen supplementation in anesthesia can block FLASH effect and anti-tumor immunity in conventional proton therapy.Communications medicine · 2023Article
- Yes‑associated protein protects and rescues SH‑SY5Y cells from ketamine‑induced apoptosis.Molecular medicine reports · 2020Article
- Desflurane and Surgery Exposure During Pregnancy Decrease Synaptic Integrity and Induce Functional Deficits in Juvenile Offspring Mice.Neurochemical research · 2020Article
- Studying Human Neurological Disorders Using Induced Pluripotent Stem Cells: From 2D Monolayer to 3D Organoid and Blood Brain Barrier Models.Comprehensive physiology · 2019Review
- Pro-Con Debate: Nitrous Oxide for Labor Analgesia.BioMed research international · 2019Review
- Neurotoxicity of Anesthesia in Children: Prevention and Treatment.Current treatment options in neurology · 2018Review
- Effects of short-term exposure to sevoflurane on the survival, proliferation, apoptosis, and differentiation of neural precursor cells derived from human embryonic stem cells.Journal of anesthesia · 2017Article
- Molecular Mechanisms of Anesthetic Neurotoxicity: A Review of the Current Literature.Journal of neurosurgical anesthesiology · 2016Review
- Various Cell Populations Within the Mononuclear Fraction of Bone Marrow Contribute to the Beneficial Effects of Autologous Bone Marrow Cell Therapy in a Rodent Stroke Model.Translational stroke research · 2016Article
- Dexmedetomidine attenuates repeated propofol exposure-induced hippocampal apoptosis, PI3K/Akt/Gsk-3β signaling disruption, and juvenile cognitive deficits in neonatal rats.Molecular medicine reports · 2016Article
- Prenatal ketamine exposure causes abnormal development of prefrontal cortex in rat.Scientific reports · 2016Article
- Anesthetic-induced developmental neurotoxicity: causes, prospective studies and possible interventions.Medical gas researchArticle
- A holistic approach to anesthesia-induced neurotoxicity and its implications for future mechanistic studies.Neurotoxicology and teratologyReview
- Ciproxifan in preventing inhalational anesthetic-induced neurotoxicity!Saudi journal of anaesthesiaArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Every year millions of young people are treated with anaesthetic agents for surgery and sedation in a seemingly safe manner. However, growing and convincing preclinical evidence in rodents and nonhuman primates, together with recent epidemiological observations, suggest that exposure to anaesthetics in common clinical use can be neurotoxic to the developing brain and lead to long-term neurological sequelae. These findings have seriously questioned the safe use of general anaesthetics in obstetric and paediatric patients. The mechanisms and human applicability of anaesthetic neurotoxicity and neuroprotection have remained under intense investigation over the past decade. Ongoing pre-clinical investigation may have significant impact on clinical practice in the near future. This review represents recent developments in this rapidly emerging field. The aim is to summarise recently available laboratory data, especially those being published after 2010, in the field of anaesthetics-induced neurotoxicity and its impact on cognitive function. In addition, we will discuss recent findings in mechanisms of early-life anaesthetics-induced neurotoxicity, the role of human stem cell-derived models in detecting such toxicity, and new potential alleviating strategies.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.