ArticleOncotarget2014
Whole genome expression profiling of blood cells in ovarian cancer patients -prognostic impact of the CYP1B1, MTSS1, NCALD, and NOP14.
Article in Oncotarget, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 31 citations in OpenAlex.
- MiRNA-related metastasis in oral cancer: moving and shaking.Cancer cell international · 2023Review
- The role of DNA methylation in ovarian cancer chemoresistance: A narrative review.Health science reports · 2023Article
- Increased expression of NOP14 is associated with improved prognosis due to immune regulation in colorectal cancer.BMC gastroenterology · 2022Article
- Article
- Analysis of the role of Ly-1 antibody reactive in different cancer types.Bioengineered · 2021Article
- The blood transcriptome prior to ovarian cancer diagnosis: A case-control study in the NOWAC postgenome cohort.PloS one · 2021Article
- LYAR Promotes Colorectal Cancer Progression by UpregulatingOxidative medicine and cellular longevity · 2021Article
- Integrated analysis of RNA-binding proteins in human colorectal cancer.World journal of surgical oncology · 2020Article
- Low expression of NCALD is associated with chemotherapy resistance and poor prognosis in epithelial ovarian cancer.Journal of ovarian research · 2020Article
- Nuclear KIT induces a NFKBIB-RELA-KIT autoregulatory loop in imatinib-resistant gastrointestinal stromal tumors.Oncogene · 2019Article
- Clinicopathological and prognostic significance of NCALD protein expression in lung adenocarcinoma.Translational cancer research · 2019Article
- High NCALD expression predicts poor prognosis of cytogenetic normal acute myeloid leukemia.Journal of translational medicine · 2019Article
- [miR-122-5p inhibits the proliferation of melanoma cells by targeting NOP14].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2018Article
- Role of lncRNA and EZH2 Interaction/Regulatory Network in Lung Cancer.Journal of Cancer · 2018Review
- Whole Blood mRNA Expression-Based Prognosis of Metastatic Renal Cell Carcinoma.International journal of molecular sciences · 2017Article
- Article
- Article
- Expression and Significances of MTSS1 in Pancreatic Cancer.Pathology oncology research : POR · 2016Article
- Article
- NOP14 suppresses breast cancer progression by inhibiting NRIP1/Wnt/β-catenin pathway.Oncotarget · 2015Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ovarian cancer patients with different tumor stages and cell differentiation might be distinguished from each other by gene expression profiles in whole blood cell mRNA by the Affymetrix Human Gene 1.0 ST Array. We also examined if there is any association with other clinical variables, response to therapy, and residual tumor burden after surgery. Patients were divided into two groups, one with poor prognosis, advanced stage and poorly differentiated tumors (n = 22), and one group with good prognosis, early stage and well- to medium differentiated tumors (n = 11). Six genes were found to be differentially expressed: the PDIA3, LYAR, NOP14, NCALD and MTSS1 genes were down-regulated and the CYP1B1 gene expression was up-regulated in the poor prognosis group, all with p value <0.05, adjusted for mass comparison. In survival analyses, CYP1B1, MTSS1, NCALD and NOP14 remained significantly different (p<0.05). Patient groups did not differ in any transcript related to acute phase or immune responses. This minimal gene expression signature of prognostic ovarian cancer-related genes opens up an avenue for more practicable monitoring of ovarian cancer patients by simple peripheral blood tests, which may evolve into a tool to guide selection of curative and postoperative supportive therapies.
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Registered trials
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