ArticleScientific reports2014
Functional divergence in gastrointestinal microbiota in physically-separated genetically identical mice.
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- Quality of methods reporting in animal models of colitis.Inflammatory bowel diseases · 2015Pooled it
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- Is it time to assignApplied and environmental microbiology · 2025Article
- Investigation of the genetic diversity of gut mycobiota of the wild and laboratory mice.Microbiology spectrum · 2025Article
- Altitude shapes gut microbiome composition accounting for diet, thyroid hormone levels, and host genetics in a subterranean blind mole rat.Frontiers in microbiology · 2024Article
- Effect of Husbandry Practices on the Fecal Microbiota of C57BL/6J Breeding Colonies Housed in 2 Different Barrier Facilities in the Same Institution.Journal of the American Association for Laboratory Animal Science : JAALAS · 2023Article
- Zebrafish: an efficient vertebrate model for understanding role of gut microbiota.Molecular medicine (Cambridge, Mass.) · 2022Review
- Cage Environment Regulates Gut Microbiota Independent of Toll-Like Receptors.Infection and immunity · 2021Article
- Shared and distinctive features of the gut microbiome of C57BL/6 mice from different vendors and production sites, and in response to a new vivarium.Lab animal · 2021Article
- Gut microbiota, NLR proteins, and intestinal homeostasis.The Journal of experimental medicine · 2020Review
- Temporospatial shifts within commercial laboratory mouse gut microbiota impact experimental reproducibility.BMC biology · 2020Article
- The microbiota influences the Drosophila melanogaster life history strategy.Molecular ecology · 2020Article
- Facility-dependent metabolic phenotype and gut bacterial composition in CD-1 mice from a single vendor: A brief report.PloS one · 2020Article
- Faecal microbiota and functional capacity associated with weaning weight in meat rabbits.Microbial biotechnology · 2019Article
- Gastrointestinal dysfunction in patients and mice expressing the autism-associated R451C mutation in neuroligin-3.Autism research : official journal of the International Society for Autism Research · 2019Article
- Article
- Diet induced obesity is independent of metabolic endotoxemia and TLR4 signalling, but markedly increases hypothalamic expression of the acute phase protein, SerpinA3N.Scientific reports · 2018Article
- Bacterial Methionine Metabolism Genes Influence Drosophila melanogaster Starvation Resistance.Applied and environmental microbiology · 2018Article
- Inflammasomes make the case for littermate-controlled experimental design in studying host-microbiota interactions.Gut microbes · 2018Article
- The role of the gut microbiota on animal model reproducibility.Animal models and experimental medicine · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite the fundamental contribution of the gut microbiota to host physiology, the extent of its variation in genetically-identical animals used in research is not known. We report significant divergence in both the composition and metabolism of gut microbiota in genetically-identical adult C57BL/6 mice housed in separate controlled units within a single commercial production facility. The reported divergence in gut microbiota has the potential to confound experimental studies using mammalian models.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.