ArticleAlcoholism, clinical and experimental research2014
Is the alcohol deprivation effect genetically mediated? Studies with HXB/BXH recombinant inbred rat strains.
Article in Alcoholism, clinical and experimental research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- The sequenced rat brain transcriptome--its use in identifying networks predisposing alcohol consumption.The FEBS journal · 2015Pooled it
- Establishing the hybrid rat diversity program: a resource for dissecting complex traits.Mammalian genome : official journal of the International Mammalian Genome Society · 2025Article
- Systems genetics approaches for understanding complex traits with relevance for human disease.eLife · 2023Review
- Beyond Genes: Inclusion of Alternative Splicing and Alternative Polyadenylation to Assess the Genetic Architecture of Predisposition to Voluntary Alcohol Consumption in Brain of the HXB/BXH Recombinant Inbred Rat Panel.Frontiers in genetics · 2022Article
- Sex and heredity are determinants of drug intake in a novel model of rat oral oxycodone self-administration.Genes, brain, and behavior · 2021Article
- Quantitative trait loci for sensitivity to acute ethanol and ethanol consummatory behaviors in rats.Alcohol (Fayetteville, N.Y.) · 2018Article
- New Rodent Population Models May Inform Human Health Risk Assessment and Identification of Genetic Susceptibility to Environmental Exposures.Environmental health perspectives · 2017Review
- Identifying genes for neurobehavioural traits in rodents: progress and pitfalls.Disease models & mechanisms · 2017Review
- Uncovering the liver's role in immunity through RNA co-expression networks.Mammalian genome : official journal of the International Mammalian Genome Society · 2016Article
- Genomic landscape of rat strain and substrain variation.BMC genomics · 2015Article
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8 authors at 4 institutions in 1 country.
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Abstract
backgroundTwo features of alcohol addiction that have been widely studied in animal models are relapse drinking following periods of alcohol abstinence and the escalation of alcohol consumption after chronic continuous or intermittent alcohol exposure. The genetic contribution to these phenotypes has not been systematically investigated.
methodsHXB/BXH recombinant inbred (RI) rat strains were given access to alcohol sequentially as follows: alcohol (10%) as the only fluid for 1 week; alcohol (10%) and water in a 2-bottle choice paradigm for 7 weeks ("pre-alcohol deprivation effect [ADE] alcohol consumption"); 2 weeks of access to water only (alcohol deprivation); and 2 weeks of reaccess to 10% alcohol and water ("post-ADE alcohol consumption"). The periods of deprivation and reaccess to alcohol were repeated 3 times. The ADE was defined as the amount of alcohol consumed in the first 24 hours after deprivation minus the average daily amount of alcohol consumed in the week prior to deprivation. Heritability of the phenotypes was determined by analysis of variance, and quantitative trait loci (QTLs) were identified.
resultsAll strains showed increased alcohol consumption, compared to the predeprivation period, in the first 24 hours after each deprivation (ADE). Broad-sense heritability of the ADEs was low (ADE1, 9.1%; ADE2, 26.2%; ADE3, 16.3%). Alcohol consumption levels were relatively stable over weeks 2 to 7. Post-ADE alcohol consumption levels consistently increased in some strains and were decreased or unchanged in others. Heritability of pre- and post-ADE alcohol consumption was high and increased over time (week 2, 38.5%; week 7, 51.1%; week 11, 56.8%; week 15, 63.3%). QTLs for pre- and post-ADE alcohol consumption were similar, but the strength of the QTL association with the phenotype decreased over time.
conclusionsIn the HXB/BXH RI rat strains, genotypic variance does not account for a large proportion of phenotypic variance in the ADE phenotype (low heritability), suggesting a role of environmental factors. In contrast, a large proportion of the variance across the RI strains in pre- and post-ADE alcohol consumption is due to genetically determined variance (high heritability).
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