Evidence map›Paper›PMID 24961288›Full record

GuidelineHPB : the official journal of the International Hepato Pancreato Biliary Association2015

Transarterial embolization therapies for the treatment of hepatocellular carcinoma: CEPO review and clinical recommendations.

Gino Boily, Jean-Pierre Villeneuve, Luc Lacoursière, Prosanto Chaudhury, Félix Couture, Jean-François Ouellet, Réal Lapointe, Stéphanie Goulet, Normand Gervais, Comité de l'évolution des pratiques en oncologie

Open access · bronzeAbstract readPractice GuidelineReview
In one paragraph

Guideline in HPB : the official journal of the International Hepato Pancreato Biliary Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

Gino BoilyInstitut national d'excellence en santé et en services sociaux, Québec, QC, Canada.
Jean-Pierre Villeneuve
Luc Lacoursière
Prosanto Chaudhury
Félix Couture
Jean-François Ouellet
Réal Lapointe
Stéphanie Goulet
Normand Gervais
Comité de l'évolution des pratiques en oncologie
Hôpital Saint-Luc · CAHôtel-Dieu de Québec · CAInstitut National d'Excellence en Santé et en Services Sociaux · CACégep de Rivière-du-Loup · CACentre intégré de santé et de services sociaux de Chaudière-Appalaches · CARoyal Victoria Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHepatocellular carcinoma (HCC) is one of the most deadly cancers in the world and its incidence rate has consistently increased over the past 15 years in Canada. Although transarterial embolization therapies are palliative options commonly used for the treatment of HCC, their efficacy is still controversial. The objective of this guideline is to review the efficacy and safety of transarterial embolization therapies for the treatment of HCC and to develop evidence-based recommendations.

methodA review of the scientific literature published up to October 2013 was performed. A total of 38 studies were included. RECOMMENDATIONS: Considering the evidence available to date, the CEPO recommends the following: (i) transarterial chemoembolization therapy (TACE) be considered a standard of practice for the palliative treatment of HCC in eligible patients; (ii) drug-eluting beads (DEB)-TACE be considered an alternative and equivalent treatment to conventional TACE in terms of oncological efficacy (overall survival) and incidence of severe toxicities; (iii) the decision to treat with TACE or DEB-TACE be discussed in tumour boards; (iv) bland embolization (TAE) not be considered for the treatment of HCC; (v) radioembolization (TARE) not be considered outside of a clinical trial setting; and (vi) sorafenib combined with TACE not be considered outside of a clinical trial setting.

Indexed as

Carcinoma, HepatocellularChemoembolization, TherapeuticHumansLiver NeoplasmsNeoplasm StagingPalliative CarePatient SelectionRisk FactorsSurvival AnalysisSurvival RateTime FactorsTreatment Outcome

Identifiers

PMID24961288
PMCPMC4266441
OpenAlexW2056330925

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.