ArticleBrain sciences2012
Striatal volume increases in active methamphetamine-dependent individuals and correlation with cognitive performance.
Article in Brain sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 60 citations in OpenAlex.
- Multimodal MRI Reveals Brain Structural Differences and Executive Dysfunction in Early Methamphetamine Abstinence.Brain and behavior · 2026Article
- A History of Methamphetamine Use Disorder in People with HIV Is Associated with Altered Functional Response to Risky Choice.Viruses · 2026Article
- Altered morphological cortical thickness and disrupted network attributes and its relationships with drug use characteristics and impulsivity in abstinent male subjects with methamphetamine use disorder.Psychological medicine · 2025Article
- Iron Deficiency Without Anemia and Reduced Basal Ganglia Iron Content in Youths.JAMA network open · 2025Article
- Individuals recently abstinent from methamphetamine show selective cognitive and behavioral differences when compared to age-matched controls.Frontiers in psychiatry · 2025Article
- Stimulant medications in children with ADHD normalize the structure of brain regions associated with attention and reward.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Cocaine self-administration behavior is associated with subcortical and cortical morphometry measures in individuals with cocaine use disorder.The American journal of drug and alcohol abuse · 2024Article
- Relationship Between Excessive Daytime Sleepiness and Caudate Nucleus Volume in Patients with Subjective Cognitive Decline: A Study from the SILCODE Using the Volbrain.Journal of Alzheimer's disease reports · 2024Article
- Independent and combined effects of methamphetamine use disorders and APOEε4 allele on cognitive performance and brain morphometry.Addiction (Abingdon, England) · 2023Article
- Impulsivity in amphetamine use disorder: Examination of sex differences.Addiction (Abingdon, England) · 2023Article
- Common and distinct fronto-striatal volumetric changes in heroin and cocaine use disorders.Brain : a journal of neurology · 2023Article
- Patients with Methamphetamine Use Disorder Show Highly Utilized Proactive Inhibitory Control and Intact Reactive Inhibitory Control with Long-Term Abstinence.Brain sciences · 2022Article
- Prior Methamphetamine Use Disorder History Does Not Impair Interoceptive Processing of Soft Touch in HIV Infection.Viruses · 2021Article
- Cognition during active methamphetamine use versus remission.Journal of clinical and experimental neuropsychology · 2021Article
- A prospective longitudinal study shows putamen volume is associated with moderate amphetamine use and resultant cognitive impairments.Psychoradiology · 2021Article
- Reduced fractional anisotropy in projection, association, and commissural fiber networks in neonates with prenatal methamphetamine exposure.Developmental neurobiology · 2020Article
- Cannabis use in patients with early psychosis is associated with alterations in putamen and thalamic shape.Human brain mapping · 2020Article
- Methamphetamine acutely alters frontostriatal resting state functional connectivity in healthy young adults.Addiction biology · 2020Article
- Gray-matter structure in long-term abstinent methamphetamine users.BMC psychiatry · 2020Article
- Alteration of Brain Structure With Long-Term Abstinence of Methamphetamine by Voxel-Based Morphometry.Frontiers in psychiatry · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effect of methamphetamine (MA) dependence on the structure of the human brain has not been extensively studied, especially in active users. Previous studies reported cortical deficits and striatal gains in grey matter (GM) volume of abstinent MA abusers compared with control participants. This study aimed to investigate structural GM changes in the brains of 17 active MA-dependent participants compared with 20 control participants aged 18-46 years using voxel-based morphometry and region of interest volumetric analysis of structural magnetic resonance imaging data, and whether these changes might be associated with cognitive performance. Significant volume increases were observed in the right and left putamen and left nucleus accumbens of MA-dependent compared to control participants. The volumetric gain in the right putamen remained significant after Bonferroni correction, and was inversely correlated with the number of errors (standardised z-scores) on the Go/No-go task. MA-dependent participants exhibited cortical GM deficits in the left superior frontal and precentral gyri in comparison to control participants, although these findings did not survive correction for multiple comparisons. In conclusion, consistent with findings from previous studies of abstinent users, active chronic MA-dependent participants showed significant striatal enlargement which was associated with improved performance on the Go/No-go, a cognitive task of response inhibition and impulsivity. Striatal enlargement may reflect the involvement of neurotrophic effects, inflammation or microgliosis. However, since it was associated with improved cognitive function, it is likely to reflect a compensatory response to MA-induced neurotoxicity in the striatum, in order to maintain cognitive function. Follow-up studies are recommended to ascertain whether this effect continues to be present following abstinence. Several factors may have contributed to the lack of more substantial cortical and subcortical GM changes amongst MA-dependent participants, including variability in MA exposure variables and difference in abstinence status from previous studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.