ArticleBrain sciences2012
Forced exercise enhances functional recovery after focal cerebral ischemia in spontaneously hypertensive rats.
Article in Brain sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 20 citations in OpenAlex.
- Synergistic benefits of melatonin and therapeutic exercise as a unified strategy for managing stroke and doxorubicin-induced cardiotoxicity.Frontiers in neurology · 2025Article
- Alterations in Striatal Architecture and Biochemical Markers' Levels During Postnatal Development in the Rat Model of an Attention Deficit/Hyperactivity Disorder (ADHD).International journal of molecular sciences · 2024Article
- Exploring the neuroprotective role of physical activity in cerebral small vessel disease.Brain research · 2024Review
- Intracerebroventricular BDNF infusion may reduce cerebral ischemia/reperfusion injury by promoting autophagy and suppressing apoptosis.Journal of cellular and molecular medicine · 2024Article
- Age-related changes in the architecture and biochemical markers levels in motor-related cortical areas of SHR rats-an ADHD animal model.Frontiers in molecular neuroscience · 2024Article
- Article
- Aging in Normotensive and Spontaneously Hypertensive Rats: Focus on Erythrocyte Properties.Biology · 2023Article
- Potential role of intermittent functioning of baroreflexes in the etiology of hypertension in spontaneously hypertensive rats.JCI insight · 2020Article
- Preventive Effects of Neuroprotective Agents in a Neonatal Rat of Photothrombotic Stroke Model.International journal of molecular sciences · 2020Article
- Maternal Treatment With Captopril Persistently Alters Gut-Brain Communication and Attenuates Hypertension of Male Offspring.Hypertension (Dallas, Tex. : 1979) · 2020Article
- Effect of stem cells-based therapy on astrogliosis in stroke subjected-mice.Stem cell investigation · 2020Article
- Neuroprotective effects of oleic acid in rodent models of cerebral ischaemia.Scientific reports · 2019Article
- The Effect of Physical Resistance Training on Baroreflex Sensitivity of Hypertensive Rats.Arquivos brasileiros de cardiologia · 2017Article
- Forced treadmill exercise can induce stress and increase neuronal damage in a mouse model of global cerebral ischemia.Neurobiology of stress · 2016Article
- Exercise-Induced Changes in Caveolin-1, Depletion of Mitochondrial Cholesterol, and the Inhibition of Mitochondrial Swelling in Rat Skeletal Muscle but Not in the Liver.Oxidative medicine and cellular longevity · 2016Article
- Comparison of surgical methods of transient middle cerebral artery occlusion between rats and mice.The Journal of veterinary medical science · 2014Article
- Middle cerebral artery occlusion methods in rat versus mouse models of transient focal cerebral ischemic stroke.Neural regeneration research · 2014Article
- Exercise and NO production: relevance and implications in the cardiopulmonary system.Frontiers in cell and developmental biology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Caveolin is the principal protein of caveolae and has been implicated in the pathogenesis of cerebral ischemia. To investigate whether changed expression of caveolins has a pivotal role in focal cerebral ischemia, we induced middle cerebral artery occlusion (MCAo)-reperfusion and examined expression of caveolins, inflammatory activation markers, and mediators of autophagic cell death. We also treated MCAo rats with forced exercise to determine its effects on neurological outcome. Particularly, spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats were used to compare the effects of hypertension on focal cerebral ischemia. All MCAo groups showed neurological deficiencies, motor dysfunction, and disruption of balancing ability; however, these pathological changes were more severe in SHR than WKY rats. Expression of caveolins was decreased in MCAo brain tissue, whereas the levels of iNOS and glial fibrillary acidic protein (GFAP) increased. Additionally, LC3-II and beclin-1 levels were elevated in the MCAo groups. Forced exercise attenuated both molecular and behavioral changes in MCAo animals, but SHR rats showed delayed functional recovery and residual molecular changes when compared to WKY rats. These results suggest that forced exercise may be beneficial for promoting functional recovery following cerebral ischemia through caveolin-dependent mechanisms or interactions between caveolins and these signaling molecules in ischemic brain regions.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.