Evidence map›Paper›PMID 24960651›Full record

Trial reportBlood transfusion = Trasfusione del sangue2015

Antibodies to Leptospira among blood donors in higher-risk areas of Australia: possible implications for transfusion safety.

Helen Faddy, Clive Seed, Colleen Lau, Vanessa Racloz, Robert Flower, Lee Smythe, Mary-Anne Burns, Michael Dohnt, Scott Craig, Robert Harley and 1 more

Open access · greenAbstract readClinical TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Blood transfusion = Trasfusione del sangue, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Helen FaddyResearch and Development, Australian Red Cross Blood Service, Brisbane, QLD, Australia School of Biomedical Sciences, Queensland University of Technology, Brisbane, QLD, Australia.
Clive SeedMedical Services, Australian Red Cross Blood Service, Perth, WA, Australia.
Colleen LauWHO Collaborating Centre for Children's Health and the Environment, Queensland Children's Medical Research Institute, The University of Queensland, Brisbane, QLD, Australia.
Vanessa RaclozSchool of Population Health, The University of Queensland, Brisbane, QLD, Australia.
Robert FlowerResearch and Development, Australian Red Cross Blood Service, Brisbane, QLD, Australia School of Biomedical Sciences, Queensland University of Technology, Brisbane, QLD, Australia.
Lee SmytheQueensland Health Forensic and Scientific Services, Brisbane, QLD, Australia.
Mary-Anne BurnsQueensland Health Forensic and Scientific Services, Brisbane, QLD, Australia.
Michael DohntQueensland Health Forensic and Scientific Services, Brisbane, QLD, Australia.
Scott CraigSchool of Biomedical Sciences, Queensland University of Technology, Brisbane, QLD, Australia Queensland Health Forensic and Scientific Services, Brisbane, QLD, Australia Faculty of Science Health and Education, University of the Sunshine Coast, Sippy Downs, QLD, Australia.
Robert HarleyMedical Services, Australian Red Cross Blood Service, Perth, WA, Australia.
Philip WeinsteinBarbara Hardy Institute, University of South Australia, Adelaide, SA, Australia.
Services Australia · AUUniversity of Queensland · AUUniversity of South Australia · AUUniversity of the Sunshine Coast · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLeptospirosis is one of the most common bacterial zoonoses worldwide, and clinical manifestations range from asymptomatic infection to acute febrile illness, multi-organ failure and death. Asymptomatic, acute bacteraemia in a blood donor provides a potential for transfusion-transmission, although only a single such case from India has been recorded. Human leptospirosis is uncommon in developed countries; however, the state of Queensland in Australia has one of the highest rates among developed countries, especially after increased rainfall. This study examined the prevalence of antibodies to Leptospira spp. in blood donors residing in higher-risk areas of Australia, to evaluate the appropriateness of current blood safety guidelines. MATERIALS AND

methodsPlasma samples collected from blood donors residing in higher-risk areas of Australia during 2009 and 2011 were included in the study. All samples were tested for the presence of antibodies to 22 leptospiral serovars using the microscopic agglutination test.

resultNo sample had antibody titres suggestive of a current or recent infection, however, seven samples (1.44%, 95% CI: 0.38-2.50%) had titres suggestive of a past infection. DISCUSSION: This study provides data that may support the appropriateness of current relevant donor selection policies in Australia. Given that the risk profile for leptospirosis is expanding and that the infection is likely to become more prevalent with climate change, this disease may become more of a concern for transfusion safety in the future.

Indexed as

Blood DonorsDonor SelectionLeptospiraAdultAntibodies, BacterialFemaleHumansLeptospirosisMaleMiddle AgedPrevalenceQueenslandAntibodies, Bacterial

Identifiers

PMID24960651
PMCPMC4317087
OpenAlexW1670189758

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.