Trial reportBlood transfusion = Trasfusione del sangue2015
Variant RH alleles and Rh immunisation in patients with sickle cell disease.
Trial report in Blood transfusion = Trasfusione del sangue, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The trial behind it
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Who cites it
30 citing papers in PubMed, 62 citations in OpenAlex.
- Transfusion strategy for weak D Type 4.0 based on RHD alleles and RH haplotypes in Tunisia.Transfusion · 2018Trial
- Identification of breakpoint regions and single nucleotide variations of RHD hybrid alleles by long-read sequencing.Vox sanguinis · 2026Article
- Characterisation of RHD and RHCE variations in blood donors from Jazan Province, Southwestern Saudi Arabia.Transfusion medicine (Oxford, England) · 2026Article
- Proof-of-principle: nanopore adaptive sampling enables full blood group genome analysis and resolution of hybrid alleles.Blood advances · 2026Article
- Article
- First investigation of RH gene polymorphism in patients with sickle cell disease and associated blood donors in Cameroon, Central Africa.Blood transfusion = Trasfusione del sangue · 2024Article
- DNA Reference Reagents for Genotyping RH Variants.The Journal of molecular diagnostics : JMD · 2024Article
- RH genotypes and red cell alloimmunization rates in chronically transfused patients with sickle cell disease: A multisite study in the USA.Transfusion · 2024Article
- A Case Report of Red Blood Cell Alloimmunization and Delayed Hemolytic Transfusion Reaction in a Patient with an Uncommon Phenotype in Sickle Cell Disease: Review of Diagnosis and Management.Case reports in hematology · 2024Article
- Proinflammatory state promotes red blood cell alloimmunization in pediatric patients with sickle cell disease.Blood advances · 2023Article
- Variant RHD alleles and Rh immunization in patients with sickle cell disease.British journal of haematology · 2023Article
- From the investigation of RHD-CE hybrid genes to the recognition of RHCE variants and RHD zygosity. Expanding the analysis by QMPSF in Brazilian donors and in patients with sickle cell disease.Blood transfusion = Trasfusione del sangue · 2023Article
- Red blood cell alloantibodies in paediatric transfusion in sub-Saharan Africa: A new cohort and literature review.EJHaem · 2023Article
- The use of pluripotent stem cells to generate diagnostic tools for transfusion medicine.Blood · 2022Article
- Accurate long-read sequencing allows assembly of the duplicated RHD and RHCE genes harboring variants relevant to blood transfusion.American journal of human genetics · 2022Article
- How to avoid the problem of erythrocyte alloimmunization in sickle cell disease.Hematology. American Society of Hematology. Education Program · 2021Review
- Rh antibodies as a result of altered Rh epitopes on transfused red cells: a case series of seven Brazilian patients.Blood transfusion = Trasfusione del sangue · 2021Article
- Pregnancies and Neonatal Outcomes in Patients with Sickle Cell Disease (SCD): Still a (High-)Risk Constellation?Journal of personalized medicine · 2021Article
- Red cell transfusion and alloimmunization in sickle cell disease.Haematologica · 2021Review
- The Significance ofFrontiers in immunology · 2021Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlloimmunisation is a major complication in patients with sickle cell disease (SCD) receiving red blood cell (RBC) transfusions and despite provision of Rh phenotyped RBC units, Rh antibodies still occur. These antibodies in patients positive for the corresponding Rh antigen are considered autoantibodies in many cases but variant RH alleles found in SCD patients can also contribute to Rh alloimmunisation. In this study, we characterised variant RH alleles in 31 SCD patients who made antibodies to Rh antigens despite antigen-positive status and evaluated the clinical significance of the antibodies produced. MATERIALS AND
methodsRHD and RHCE BeadChip™ from BioArray Solutions and/or amplification and sequencing of exons were used to identify the RH variants. The serological features of all Rh antibodies in antigen-positive patients were analysed and the clinical significance of the antibodies was evaluated by retrospective analysis of the haemoglobin (Hb) levels before and after transfusion; the change from baseline pre-transfusion Hb and the percentage of HbS were also determined.
resultsWe identified variant RH alleles in 31/48 (65%) of SCD patients with Rh antibodies. Molecular analyses revealed the presence of partial RHD alleles and variant RHCE alleles associated with altered C and e antigens. Five patients were compound heterozygotes for RHD and RHCE variants. Retrospective analysis showed that 42% of antibodies produced by the patients with RH variants were involved in delayed haemolytic transfusion reactions or decreased survival of transfused RBC. DISCUSSION: In this study, we found that Rh antibodies in SCD patients with RH variants can be clinically significant and, therefore, matching patients based on RH variants should be considered.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.